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Title of Journal: Int Urogynecol J

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Abbravation: International Urogynecology Journal

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Springer London

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DOI

10.1007/bf03255012

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1433-3023

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Fibroblasts from women with pelvic organ prolapse

Authors: Alejandra M RuizZapata Manon H Kerkhof Behrouz ZandiehDoulabi Hans A M Brölmann Theo H Smit Marco N Helder
Publish Date: 2013/04/12
Volume: 24, Issue: 9, Pages: 1567-1575
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Abstract

Little is known about dynamic cellmatrix interactions in the context of pathophysiology and treatments for pelvic organ prolapse POP This study sought to identify differences between fibroblasts from women with varying degrees of prolapse in reaction to mechanical stimuli and matrix substrates in vitroFibroblasts from the vaginal wall of three patients with POP Quantification POPQ system stages 0 II and IV were stretched on artificial polymer substrates either coated or not coated with collagen I Changes in morphology and anabolic/catabolic compounds that affect matrix remodelling were evaluated at protein and geneexpression levels Statistical analysis was performed using oneway analysis of variance ANOVA followed by TukeyKramer’s post hoc test

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