Authors: Davide De Vita Salvatore Giordano
Publish Date: 2012/05/22
Volume: 23, Issue: 12, Pages: 1707-1713
Abstract
Women with RBC were randomized to intravesical HA 800 mg and chondroitin sulfate CS 1 g IALURIL® IBSA in 50 mL of saline solution once weekly for 4 weeks then once every 2 weeks twice more group 1 or long term antibiotic prophylaxis using sulfamethoxazole 200 mg and trimethoprim 40 mg once weekly for 6 weeks group 2 control Evaluations included cystitis recurrence at 2 and 12 months subjective pain symptoms visual analog scale VAS 3 day voiding sexual function quality of life Kings Health Questionnaire KHQ frequency symptoms/frequency symptoms PUF symptom scale and maximum cystometric capacity MCC Means ± standard deviations were reported with MannWhitney test for betweengroup comparison significance P 05Of 28 women mean age 60 ± 13 y randomized 26 completed followup mean followup 115 mo Group 1 showed a significant improvement in all evaluations cystitis recurrence 1 ± 12 versus 23 ± 14 P = 02 3day voiding mean 178 ± 35 vs 242 ± 83 P = 04 symptom VAS 16 ± 08 vs 78 ± 16 P 001 PUF score 112 ± 27 vs 196 ± 22 P 001 KHQ score 184 ± 72 vs 473 ± 136 P 001 and MCC 380 ± 78 vs 229 ± 51 mL P 001 vs group 2 at 12 mo No adverse effects were recordedIntravesical HA and CS in combination significantly reduced cystitis recurrence and improved urinary symptoms quality of life and cystometric capacity in RBC patients at 12 mo followup versus antibiotic prophylaxis Study limitations include a small sample and relatively short followupNeither of the authors have anything to disclose Neither author has any commercial associations or disclosures that may pose or create any conflict of interest with information presented in this manuscript This was an independent study and the funding support from IBSA Institut Biochimique SA was limited to editorial assistance
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