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Title of Journal: Int Urogynecol J

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Abbravation: International Urogynecology Journal

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Springer London

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DOI

10.1007/b139095

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1433-3023

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Urinary nerve growth factor correlates with the se

Authors: Sang Woon Kim Young Jae Im Ho Chul Choi Hyo Jin Kang Ji Yu Kim Jang Hwan Kim
Publish Date: 2014/05/28
Volume: 25, Issue: 11, Pages: 1561-1567
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Abstract

Urinary nervegrowthfactor NGF level reflected the severity of urgency in patients with lower urinary tract symptoms LUTS and pain in patients with Bladder pain syndrome/interstitial cystitis BPS/IC The aim of this study was to investigate the levels of biomarkers nerve growth factor NGF and prostaglandin E2 PGE2 among disease groups sharing similar urinary symptoms and to elucidate which symptoms are related to individual biomarker levelsWe studied 83 patients with LUTS who visited our outpatient clinic from May 2011 to December 2012 On the basis of clinical symptoms and a 3day voiding diary patients were classified into three groups those with frequency n = 13 overactive bladder OAB n = 35 and BPS/IC n = 35 Patients with stress urinary incontinence SUI or microscopic hematuria served as controls n = 24 Storage symptoms were evaluated based on OAB symptom score OABSSMean patient age was 6208 ± 1147 range 23–84 Urinary NGF and creatininenormalized NGF levels were significantly increased in those with OAB 20190 and 408 respectively and BPS/IC 17371 and 272 compared with controls 7777 and 129 and those with frequency 6776 and 123 Neither value significantly differed between OAB and BPS/IC patients or between controls and frequency patients Urinary PGE2 and creatininenormalized PGE2 levels were not significantly different among groups On linear regression analysis urinary NGF levels were significantly correlated with urgency severity overall R = 0222 and also pain in BPS/IC patients R = 0409

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