Authors: Pedro Bekinschtein Cynthia Katche Leandro Slipczuk Carolina Gonzalez Guido Dorman Martín Cammarota Iván Izquierdo Jorge H Medina
Publish Date: 2010/02/12
Volume: 18, Issue: 3-4, Pages: 377-385
Abstract
Although much is known about longterm memory LTM consolidation what puts the “long” in LTM is the exclusive feature of persisting over time However until recently the molecular mechanisms underneath memory persistence had never been properly studied In rats the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12 h after inhibitory avoidance IA training without affecting memory formation Here we also show learninginduced changes in hippocampal cFos Homer 1a Akt CamKIIα and ERK2 levels around 18–24 h after IA training Thus memory persistence is associated with a late phase of plasticityrelated protein synthesis in the hippocampus
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