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Title of Journal: Neurotox Res

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Abbravation: Neurotoxicity Research

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Springer US

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DOI

10.1016/0006-8993(95)01077-7

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1476-3524

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Developmental Exposure to Very Low Levels of Ethyn

Authors: Marco Zaccaroni Daniele Della Seta Francesca Farabollini Leonida Fusani Francesco DessìFulgheri
Publish Date: 2016/06/29
Volume: 30, Issue: 4, Pages: 553-562
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Abstract

Ethinylestradiol EE2 a synthetic mimic of 17βestradiol is widespread in the environment because of its use as a contraceptive In mammals recent research highlighted behavioral physiological and morphological effects of exposition to EE2 this xenoestrogen We studied if developmental exposure to environmentallike low doses of EE2 affects measures of anxiety in Sprague–Dawley rats We treated male and female rats with two doses of EE2 4 and 400 ng/kg/day either from GD 5 through PND 32 or from PND 1 through 21 Effects on anxiety were tested by novel place preference tests In males and females treated from GD 5 through PND 32 a significant reduction of the time passed in the novel environment was observed The decrease of the time spent in the novel compartment and the increase in the number of transitions between familiar and novel compartments indicate increased levels of anxiety in the EE2treated subjects These studies suggest that exposure to very low doses of EE2 during development can affect key behavioral traits that are modulated by anxiety


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  2. The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis
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  6. Erratum to: Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson’s Disease
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  11. Chronic Pretreatment with Acetyl- l -Carnitine and ±DL-α-Lipoic Acid Protects Against Acute Glutamate-Induced Neurotoxicity in Rat Brain by Altering Mitochondrial Function
  12. Evaluation of the Neurotoxic/Neuroprotective Role of Organoselenides Using Differentiated Human Neuroblastoma SH-SY5Y Cell Line Challenged with 6-Hydroxydopamine
  13. Organochalcogens Inhibit Mitochondrial Complexes I and II in Rat Brain: Possible Implications for Neurotoxicity
  14. Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures

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