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Title of Journal: Radiol med

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Abbravation: La radiologia medica

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Springer Milan

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DOI

10.1007/978-0-387-76487-0_11

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1826-6983

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CT perfusion in solidbody tumours Part I techni

Authors: G Petralia L Preda G D’Andrea S Viotti L Bonello R De Filippi M Bellomi
Publish Date: 2010/02/22
Volume: 115, Issue: 6, Pages: 843-857
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Abstract

Functional imaging is becoming increasingly important in both research and clinical diagnostic radiology Perfusion computed tomography CTP is a readily available and widely used tool that allows an objective measurement of tissue perfusion through the mathematical analysis of data obtained from repeated scans performed after administration of contrast agent Recently CTP has been increasingly used in the oncological field being studied as a potential marker of neoplastic angiogenesis which is one of the main targets of new tumour therapies The aim of this paper was to provide the theoretical background and practical guidance for accurately performing CTP and interpreting results of examinations in solidbody tumours CTP could be a valid tool for functional imaging of tumours if the acquisition technique is robust if image and data analysis is accurate and if interpretation of results is adequately inserted within a clinical contextL’imaging funzionale sta acquisendo un ruolo sempre più importante sia nella ricerca che nell’attività clinica della diagnostica per immagini La tomografia computerizzata perfusionale TCp è una tecnica ampiamente disponibile e diffusa sul territorio che permette di misurare oggettivamente la perfusione di un tessuto attraverso l’analisi matematica dei dati ottenuti da scansioni ripetute nel tempo dopo la somministrazione di mezzo di contrasto La TCp ha recentemente visto ampliare il suo impiego in ambito oncologico perché viene studiata come possibile marcatore della angiogenesi neoplastica che è uno dei principali target delle nuove terapie dei tumori Scopo di questo lavoro è descrivere i presupposti teorici e fornire indicazioni pratiche per eseguire correttamente ed interpretare i risultati di esami di TCp sui tumori solidi del corpo La TCp potrebbe essere uno valido strumento per l’imaging funzionale dei tumori se la tecnica di acquisizione è robusta se l’analisi di immagini e dati è accurata e se l’interpretazione dei risultati è adeguatamente inserita nel contesto clinico


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