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Title of Journal: Radiol med

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Abbravation: La radiologia medica

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Springer Milan

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DOI

10.1002/chem.201304905

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1826-6983

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Prognosis of local recurrence in giant cell tumour

Authors: Yifeng He Ji Zhang Xiaoyi Ding
Publish Date: 2017/03/07
Volume: 122, Issue: 7, Pages: 505-519
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Abstract

Giant cell tumour of bone GCTB is classified as an intermediate tumour with rare metastasis but is challenged by local recurrence This review focuses on the role of radiological evaluation in terms of prognosis of local recurrence in GCTB We hope to highlight the value of radiological evaluation by integrating studies on the impact of surgical treatments and nonsurgical factors on local recurrence of GCTB and the current statuses of genetic and molecular prognostic factors of GCTB Radiological evaluation can provide diverse information on tumours As a noninvasive method magnetic resonance imaging MRI is especially valuable for the diagnosis and evaluation of bone tumours due to its heightened sensitivity to soft tissue disease and multiplanar image acquisition Imaging findings should be integrated with clinical characteristics pathology and genetic and molecular prognostic factors to direct clinical approach and reduce the local recurrence of GCTB Therefore it is necessary to establish a multiperspective evaluation system by which prognostic factors can be reliably determined We further advocate more largescale prospective studies With the help of radiological evaluation the clinic treatment of GCTB can be guided and local recurrence might be reduced additionally MR imaging can identify local recurrence of GCTB after surgical treatment in the early stage

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