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Title of Journal: Radiol med

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Abbravation: La radiologia medica

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Springer Milan

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DOI

10.1007/bf03311201

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1826-6983

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Stereotactic body radiotherapy for cardiac and par

Authors: Pierluigi Bonomo Lorenzo Livi Andrea Rampini Icro Meattini Benedetta Agresti Gabriele Simontacchi Fabiola Paiar Monica Mangoni Ivano Bonucci Daniela Greto Laura Masi Raffaella Doro Livia Marrazzo Giampaolo Biti
Publish Date: 2013/05/28
Volume: 118, Issue: 6, Pages: 1055-1065
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Abstract

This study sought to evaluate acute toxicity and local control in patients who underwent extracranial stereotactic body radiation therapy SBRT for paracardiac and cardiac metastatic lesions defined as such when located at a maximum distance of 1 cm from the heart or inside its parenchymaBetween January 2009 and May 2011 16 patients with paracardiac and cardiac lesions were treated with SBRT For dose specification in 15 of 16 patients the prescription dosage was 36 Gy in three fractions 70 isodose In one patient the target lesion was inside the heart and the prescription dosage was 30 Gy in three fractions 70 isodoseRegarding response to stereotactic radiotherapy we recorded one 6 complete response CR six 37 partial responses PR five 32 stable disease SD and four 25 local failures Median interval to local failure was 52 range 3–12 months The cause of death was distant progression of disease in all four patients Compliance to treatment was excellent no patient developed cardiological symptoms or electrocardiographic abnormalities even months after SBRTScopo di questo lavoro è valutare la tossicità acuta e il controllo locale nel trattamento di pazienti sottoposti a radioterapia stereotassica extracranica SBRT per lesioni metastatiche paracardiache e cardiache definite come tali se localizzate entro 1 cm dal cuore o nel contesto del suo parenchimaFra gennaio 2009 e maggio 2011 16 pazienti con lesioni paracardiache e cardiache sono stati sottoposti a SBRT In 15/16 pazienti la dose prescritta è stata di 36 Gy in 3 frazioni all’isodose del 70 In un paziente la lesione target era intracardiaca e la dose di prescrizione è stata di 30 Gy in 3 frazioni all’isodose del 70Per quanto concerne la risposta alla radioterapia stereotassica è stata registrata 1 6 risposta completa CR 6 37 risposte parziali PR 5 32 stabilità di malattia SD e 4 25 progressioni locali L’intervallo mediano alla progressione locale è stato di 52 mesi range 3–12 mesi La tolleranza al trattamento è stata ottimale nella serie di pazienti trattati nessuno ha sviluppato segni o sintomi di natura cardiologica in conseguenza della SBRT


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