Authors: Reinhold Ramoner Andrea Rahm Claudia E Falkensammer Nicolai Leonhartsberger Martin Thurnher
Publish Date: 2010/02/25
Volume: 59, Issue: 8, Pages: 1141-1147
Abstract
In contrast to hematologic malignancies little is known about the role of fungi in the development and progression of solid tumors This prompted us to analyze and correlate serum levels of different fungal IgG with survival of patients with metastatic renal cell carcinomaMedian followup was 290 months range 03–122 Median overall survival of patients which tested negative for Candida IgG was significantly increased median not reached 29 months compared with Candida IgG positive patients 178 months P = 0002 Median survival of Saccharomyces IgG negative patients was 331 months as opposed to 194 months in Saccharomyces IgG positive patients although this difference was not significant P = 0281 No difference in overall survival was found between Aspergillus IgG positive patients 280 months and Aspergillus IgG negative patients 291 months P = 0181 Cox backwardstepwise regression confirmed Candida IgG as the strongest predictor of survival in metastatic renal cell carcinoma patients risk ratio 327 P = 0001 95 CI 186–573
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