Journal Title
Title of Journal: Cancer Immunol Immunother
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Abbravation: Cancer Immunology, Immunotherapy
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Publisher
Springer-Verlag
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Authors: Lujun Chen Xiao Zheng Yueping Shen Yibei Zhu Qing Li Junjun Chen Rui Xia Shuming Zhou Changping Wu Xueguang Zhang Binfeng Lu Jingting Jiang
Publish Date: 2012/10/23
Volume: 62, Issue: 3, Pages: 553-561
Abstract
In the present study we studied the expression of Tbet a key marker for type 1 immune responses within the tumor microenvironment of gastric cancer and analyzed its association with clinicopathological parameters One hundred and fiftytwo archival paraffinembedded gastric tumor tissues were collected and the expression of Tbet in these cancer tissue specimens was examined by immunohistochemistry Tbet+ tumorinfiltrating lymphocytes TILs in some gastric cancer tissues were further characterized by flow cytometric analysis The density of Tbet+ TILs in gastric cancer tissues in relation to patient’s clinicopathological parameters and postoperative prognosis has been analyzed Herein we have found significant increases in Tbet+ lymphocytes in tumor tissues as compared with normal stomach tissues gastritis tissues or gastric polyp specimens Tbet+ cells mainly consisted of CD4+ CD8+ and CD56+ TILs In addition lower numbers of Tbet+ TILs were associated with poor clinicopathological parameters such as invasion to muscular layer larger tumor size and advanced cancer stages Moreover patients with higher numbers of Tbet+ TILs have longer diseasefree survival and overall survival Thus our study supports the idea that tumor growth elicits spontaneous type 1 cellular immune responses and tumor progression is associated with suppression of antitumor immunity Tbet expression within tumor can serve as a prognostic indicator for gastric cancer and a potential biomarker for immunotherapyWe thank senior pathologists Changqing Lu Wei Zhao Jun Xie and Yuandong Chen Department of Pathology The Third Affiliated Hospital of Soochow University Jiangsu Changzhou China for their expert suggestions and technical assistances This work was supported in part by grants from the National Natural Science Foundation of China No 81171653 31170866 30950022 and 30972703 Jiangsu Province Science and Technology Innovation Fund 201285 and the Innovative Talents Training Project of Changzhou Health Bureau
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- Successful induction of clinically competent dendritic cells from granulocyte colony-stimulating factor-mobilized monocytes for cancer vaccine therapy
- Second International Symposium on Cancer Biology (ISCB), November 14–16, 2011, at the National Institute of Immunology, New Delhi, India
- Cancer/testis antigens expression and autologous serological response in a set of Brazilian non-Hodgkin’s lymphoma patients
- Saccharomyces cerevisiae , the Baker’s Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice
- Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E 2 results in high interleukin-12 production and cell migration
- Increase in CD14 + HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
- CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells
- Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma
- Epigenetic regulation of immune escape genes in cancer
- The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis
- Dendritic cells efficiently acquire and present antigen derived from lung cancer cells and induce antigen-specific T-cell responses
- Expression of complement protein C5a in a murine mammary cancer model: tumor regression by interference with the cell cycle
- −509C>T polymorphism in the TGF-β1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection
- Bridging the innate and adaptive immune responses against cancer: 95th AACR meeting 2004
- Heterogeneity of CD8 + tumor-infiltrating lymphocytes in non-small-cell lung cancer: impact on patient prognostic assessments and comparison of quantification by different sampling strategies
- Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma
- Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report
- Early developmental expression of a normally tumor-associated and drug-inhibited cell surface-located NADH oxidase (ENOX2) in non-cancer cells
- Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms
- H 2 O 2 production within tumor microenvironment inversely correlated with infiltration of CD56 dim NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction
- Lenalidomide enhances anti-myeloma cellular immunity
- Epidemiology: allergy history, IgE, and cancer
- Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A
- Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study
- Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion
- Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
- Chordoma and chondrosarcoma gene profile: implications for immunotherapy
- Serum IgG against Candida predict survival in patients with metastatic renal cell carcinoma
- Extracellular adenosine metabolism in immune cells in melanoma
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- Phase I–II study of lenalidomide and alemtuzumab in refractory chronic lymphocytic leukemia (CLL): effects on T cells and immune checkpoints
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- Comparison of AAV/IL-7 autocrine (T cell) versus paracrine (DC) gene delivery for enhancing CTL stimulation and function
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