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Title of Journal: Cancer Immunol Immunother

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Abbravation: Cancer Immunology, Immunotherapy

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Springer Berlin Heidelberg

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DOI

10.1002/hyp.10122

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ISSN

1432-0851

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Cardiac allograft rejection as a complication of P

Authors: Taofeek K Owonikoko Mukesh Kumar Shu Yang Alice O Kamphorst Rathi N Pillai Rama Akondy Vivek Nautiyal Monica S Chatwal Wendy M Book Anurag Sahu Gabriel L Sica Rafi Ahmed Suresh S Ramalingam
Publish Date: 2016/10/22
Volume: 66, Issue: 1, Pages: 45-50
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Abstract

The mechanism of cardiac allograft rejection in the context of PD1 antibody therapy was explored in a patient with cutaneous squamous cell cancer complicating longstanding cardiac allograft Immune cell infiltrate in the myocardium and peripheral blood lymphocyte repertoire were assessed using myocardial biopsy and temporal analysis of peripheral blood samples The efficacy of highintensity immunosuppression to reverse graft rejection was exploredEndomyocardial biopsy showed acute moderate diffuse cellular rejection with a predominant population of CD3+ CD8+ and CD4+ infiltrating lymphocytes peripheral blood circulating lymphocytes showed a high frequency of proliferating and activated CD8+ T cells expressing PD1 compared to a normal control There was no difference in the activation and proliferation of CD4+ T cells compared to a normal control Cardiac function improved following highintensity immunosuppression and patient survived for up to 7 months after discontinuation of nivolumab

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