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Title of Journal: Cancer Immunol Immunother

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Abbravation: Cancer Immunology, Immunotherapy

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Springer-Verlag

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DOI

10.1007/s13191-013-0339-6

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1432-0851

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HSubscript2/SubscriptOSubscript2/Subscript

Authors: Shinichirou Izawa Koji Kono Kousaku Mimura Yoshihiko Kawaguchi Mitsuaki Watanabe Takanori Maruyama Hideki Fujii
Publish Date: 2011/08/03
Volume: 60, Issue: 12, Pages: 1801-1810
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Abstract

Human NK cells can be divided into two subsets CD56dimCD16+NK and CD56brightCD16−NK cells based on their expression of CD56 and CD16 In the present study we analyzed the relationship between CD56dim/CD56bright NK cells and H2O2 in tumorinfiltrating NK cells in patients with gastric n = 50 and esophageal n = 35 cancer The ratio of CD56dim NK cells infiltrating tumors gradually decreased according to disease progression H2O2 was abundantly produced within tumor microenvironments and there was an inverse correlation between CD56dim NK cell infiltration and H2O2 production CD56dim NK cells are more sensitive to apoptosis induced by physiological levels of H2O2 than CD56bright NK cells Furthermore the exposure of NK cells to H2O2 resulted in the impairment of ADCC activity In conclusion H2O2 produced within tumor microenvironments inversely correlated with the infiltration of CD56dim NK cells possibly due to their preferentially induced cell death These observations may explain one of the mechanisms behind NK cell dysfunction frequently observed in tumor microenvironments

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