Journal Title
Title of Journal: Cancer Immunol Immunother
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Abbravation: Cancer Immunology, Immunotherapy
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Publisher
Springer Berlin Heidelberg
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Authors: Pauline M W van Kempen Rob Noorlag Justin E Swartz Niels Bovenschen Weibel W Braunius Jeroen F Vermeulen Ellen M Van Cann Wilko Grolman Stefan M Willems
Publish Date: 2016/03/18
Volume: 65, Issue: 5, Pages: 575-585
Abstract
Patients with human papillomavirus HPVpositive oropharyngeal squamous cell carcinomas OPSCCs have an improved prognosis compared to HPVnegative OPSCCs Several theories have been proposed to explain this relatively good prognosis One hypothesis is a difference in immune response In this study we compared tumorinfiltrating CD3+ CD4+ CD8+ Tcells and granzyme inhibitors SERPINB1 SERPINB4 and SERPINB9 between HPVpositive and HPVnegative tumors and the relation with survivalProtein expression of tumorinfiltrating lymphocytes TILs CD3 CD4 and CD8 and granzyme inhibitors was analyzed in 262 OPSCCs by immunohistochemistry IHC Most patients 67 received primary radiotherapy with or without chemotherapy Cox regression analysis was carried out to compare overall survival OS of patients with low and high TIL infiltration and expression of granzyme inhibitorsHPVpositive OPSCCs were significantly more heavily infiltrated by TILs p 0001 compared to HPVnegative OPSCCs A high level of CD3+ TILs was correlated with a favorable outcome in the total cohort and in HPVpositive OPSCCs while it reached no significance in HPVnegative OPSCCs There was expression of all three granzyme inhibitors in OPSCCs No differences in expression were found between HPVpositive and HPVnegative OPSCCs Within the group of HPVpositive tumors a high expression of SERPINB1 was associated with a significantly worse overall survivalHPVpositive OPSCCs with a low count of CD3+ TILs or high expression of SERPINB1 have a worse OS comparable with HPVnegative OPSCCs This suggests that the immune system plays an important role in the carcinogenesis of the virally induced oropharynx tumors
Keywords:
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Other Papers In This Journal:
- Successful induction of clinically competent dendritic cells from granulocyte colony-stimulating factor-mobilized monocytes for cancer vaccine therapy
- Second International Symposium on Cancer Biology (ISCB), November 14–16, 2011, at the National Institute of Immunology, New Delhi, India
- Cancer/testis antigens expression and autologous serological response in a set of Brazilian non-Hodgkin’s lymphoma patients
- Saccharomyces cerevisiae , the Baker’s Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice
- Higher numbers of T-bet + intratumoral lymphoid cells correlate with better survival in gastric cancer
- Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E 2 results in high interleukin-12 production and cell migration
- Increase in CD14 + HLA-DR −/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
- CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells
- Soluble factors released by activated cytotoxic T lymphocytes interfere with death receptor pathways in neuroblastoma
- Epigenetic regulation of immune escape genes in cancer
- The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis
- Dendritic cells efficiently acquire and present antigen derived from lung cancer cells and induce antigen-specific T-cell responses
- Expression of complement protein C5a in a murine mammary cancer model: tumor regression by interference with the cell cycle
- −509C>T polymorphism in the TGF-β1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infection
- Bridging the innate and adaptive immune responses against cancer: 95th AACR meeting 2004
- Heterogeneity of CD8 + tumor-infiltrating lymphocytes in non-small-cell lung cancer: impact on patient prognostic assessments and comparison of quantification by different sampling strategies
- Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma
- Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report
- Early developmental expression of a normally tumor-associated and drug-inhibited cell surface-located NADH oxidase (ENOX2) in non-cancer cells
- Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms
- H 2 O 2 production within tumor microenvironment inversely correlated with infiltration of CD56 dim NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction
- Lenalidomide enhances anti-myeloma cellular immunity
- Epidemiology: allergy history, IgE, and cancer
- Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A
- Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study
- Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion
- Chordoma and chondrosarcoma gene profile: implications for immunotherapy
- Serum IgG against Candida predict survival in patients with metastatic renal cell carcinoma
- Extracellular adenosine metabolism in immune cells in melanoma
- Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity
- Phase I–II study of lenalidomide and alemtuzumab in refractory chronic lymphocytic leukemia (CLL): effects on T cells and immune checkpoints
- Comparative analysis of monocytic and granulocytic myeloid-derived suppressor cell subsets in patients with gastrointestinal malignancies
- Comparison of AAV/IL-7 autocrine (T cell) versus paracrine (DC) gene delivery for enhancing CTL stimulation and function
- Non-genomic events determining the sensitivity of hemopoietic malignancies to glucocorticoid-induced apoptosis
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