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Title of Journal: Sci China Chem

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Abbravation: Science China Chemistry

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SP Science China Press

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1862-2771

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Study on the αcyclodextrin/polyethylene glycol

Authors: Yuan Li Li Ji Gang Wang LiQing Song Bin He Li Li Yu Nie Yao Wu ZhongWei Gu
Publish Date: 2010/03/31
Volume: 53, Issue: 3, Pages: 495-501
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Abstract

This paper reports the synthesis and drug delivery properties of a novel supramolecular nanoparticle αCyclodextrins αCD were threaded on cinnamic acid modified polyethylene glycol to form inclusion complex nanoparticles by supramolecular selfassemble The antitumor drug doxorubicin was loaded in the nanoparticles and released in vitro to study the drug release behavior and the antitumor effects The structure and morphology of the nanoparticles were characterized by nuclear magnetic resonance Xray diffraction ultraviolet absorbance dynamic laser scattering scanning electronic microscopy transmission electron microscopy and atom force microscopy The distribution of the drug loaded nanoparticles in cells and the antitumor effects were studied by confocal laser microscopy The results demonstrate that the supramolecular nanoparticle is biocompatible and it is a promising carrier for drug delivery systems

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