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Title of Journal: Sci China Chem

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Abbravation: Science China Chemistry

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Science China Press

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DOI

10.1007/bf03323937

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1869-1870

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Superresolution imaging of telomeres with continuo

Authors: Shaopeng Wang Suhui Deng Xiaoqing Cai Shangguo Hou Jiajun Li Zhaoshuai Gao Jiang Li Lihua Wang Chunhai Fan
Publish Date: 2016/06/28
Volume: 59, Issue: 11, Pages: 1519-1524
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Abstract

The significant role of telomeres in cells has attracted much attention since they were discovered Fluorescence imaging is an effective method to study subcellular structures like telomeres However the diffraction limit of traditional optical microscope hampers further investigation on them Recent progress on superresolution fluorescence microscopy has broken this limit In this work we used stimulated emission depletion STED microscope to observe fluorescencelabeled telomeres in interphase cell nuclei The results showed that the size of fluorescent puncta representing telomeres under the STED microscope was much smaller than that under the confocal microscope Two adjacent telomeres were clearly separated via STED imaging which could hardly be discriminated by confocal microscopy due to the diffraction limit We conclude that STED microscope is a more powerful tool that enable us to obtain detailed information about telomeres

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