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Title of Journal: Sci China Chem

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Abbravation: Science China Chemistry

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Science China Press

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DOI

10.1002/ange.19250383203

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1869-1870

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Effect of glutathione on Emphasis Type="Italic"i

Authors: Yizhuan Huang Xiaolan Chen Saige Shi Mei Chen Shaoheng Tang Shiguang Mo Jingping Wei Nanfeng Zheng
Publish Date: 2015/05/14
Volume: 58, Issue: 11, Pages: 1753-1758
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Abstract

Plasmonic Pd nanosheets have been emerging as promising materials for applying in nearinfrared NIR photothermal therapy PTT of cancer However animal in mice studies indicated that the original synthesized polyvinylpyrrolidone PVPprotected small Pd nanosheets PdPVP and some further surfacemodified small Pd nanosheets such as PdPEGSH easily accumulated in reticuloendothelial system RES organs liver spleen etc and were difficult to be cleared from these organs quickly In the work we surprisingly found that glutathione GSH could promote the clearance of surfacemodified small Pd nanosheets eg PdPVP PdPEGSH and PdGSH from the RES organs efficiently The effects of GSH on the biodistribution and clearance of different surfacemodified Pd nanosheets were investigated Our results indicated that these surfacemodified Pd nanosheets with or without GSH added caused no morbidity at target primary organs and GSH can promote the clearance of different surfacemodified Pd nanosheets in the order of PdPVP≈PdPEGSHPdGSH This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems RES

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