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Title of Journal: Sci China Chem

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Abbravation: Science China Chemistry

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SP Science China Press

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DOI

10.1007/s002880050013

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ISSN

1869-1870

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Synthesis and antitumor activities of a new series

Authors: DeXiang Guo YaJing Liu Ting Li Nan Wang Xin Zhai Chun Hu Ping Gong
Publish Date: 2012/01/04
Volume: 55, Issue: 3, Pages: 347-351
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Abstract

A new series of 45dihydro1Hthiochromeno43dpyrimidine derivatives have been designed and synthesized The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 human alveolar adenocarcinoma cell and H460 human lung cancer by MTT assay Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines The most potent compound 4benzod13dioxol5yl89difluoro24methylpiperazin1yl45dihydro1Hthiochromeno43dpyrimidine CH05 IC50 = 044 μM 307 μM was 20 and 84 times more active than gefitinib IC50 = 089 μM 1681 μM against A549 and H460 cell lines respectively

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  13. Multi-component hydrogen-bonding salts formed between imidazole and aromatic acids: Synthons cooperation and crystal structures
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