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Title of Journal: Cerebellum

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Abbravation: The Cerebellum

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Springer-Verlag

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DOI

10.1007/s00604-003-0080-7

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1473-4230

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TType Calcium Channel as a New Therapeutic Target

Authors: Hideto Miwa Tomoyoshi Kondo
Publish Date: 2011/04/12
Volume: 10, Issue: 3, Pages: 563-569
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Abstract

Voltagegated calcium channels play an important role in many physiological and pathological processes Accumulating studies suggest that the Ttype calcium channel is a potential target for the treatment of various neurological disorders such as epilepsy insomnia and neuropathic pain Here we highlight recent advances in our understanding of Ttype calcium channel regulation and their implications for tremor disorders Several Ttype calcium channel blockers effectively suppressed experimental tremors that have been suggested to originate from either the cerebellum or basal ganglia Among Ttype calcium channel blockers that have been used clinically the antitremor efficacy of zonisamide garnered our attention Based on both basic and clinical studies the possibility is emerging that Ttype calcium channel blockers that transit into the central nervous system may have therapeutic potentials for tremor disorders

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Other Papers In This Journal:
  1. Cerebellum: from Fundamentals to Translational Approaches. The Seventh International Symposium of the Society for Research on the Cerebellum
  2. Cerebellar Contribution to Anger Recognition Deficits in Huntington’s Disease
  3. Compartmentation of the Cerebellar Cortex in the Naked Mole-Rat ( Heterocephalus glaber )
  4. Behavioural Significance of Cerebellar Modules
  5. An fMRI Investigation of Cerebellar Function During Verbal Working Memory in Methadone Maintenance Patients
  6. Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum
  7. Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations
  8. Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease
  9. A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder
  10. Spinal Cord Atrophy Correlates with Disability in Friedreich’s Ataxia
  11. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  12. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  13. Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases
  14. Cerebellum and Personality Traits
  15. Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
  16. Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
  17. Increased Catabolic State in Spinocerebellar Ataxia Type 1 Patients
  18. Mild Clinical and Biochemical Phenotype in Two Patients with PMM2-CDG (Congenital Disorder of Glycosylation Ia)
  19. Cerebellar Function in Developmental Dyslexia
  20. Glutamate Dysfunction Associated with Developmental Cerebellar Damage: Relevance to Autism Spectrum Disorders
  21. Non-Ataxic Presenting Symptoms of Dominant Ataxias
  22. Asymmetries in Cerebellar Plasticity and Motor Learning
  23. Clinical Manifestations of Cerebellar Infarction According to Specific Lobular Involvement
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