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Title of Journal: Cerebellum

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Abbravation: The Cerebellum

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Springer-Verlag

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DOI

10.1007/s00521-016-2782-x

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1473-4230

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Regional Cerebellar Volumes Predict Functional Out

Authors: MarieEve Bolduc Adre J du Plessis Nancy Sullivan Nicolas Guizard Xun Zhang Richard L Robertson Catherine Limperopoulos
Publish Date: 2011/09/07
Volume: 11, Issue: 2, Pages: 531-542
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Abstract

The cerebellum has recently been recognized for its role in highorder functions including cognition language and behavior Recent studies have also begun to describe a functional topography of the mature cerebellum that includes organization on a mediolateral axis However no study to date has examined the relationship between regional cerebellar volume and developmental disabilities in children with cerebellar malformations The objective of this study was to estimate the extent to which total and regional cerebellar volumes are associated with developmental disabilities in a cohort of children with cerebellar malformations Children aged 1 to 6 years with a diagnosis of cerebellar malformation underwent standardized outcome measures and quantitative magnetic resonance scanning The cerebellum was parcellated into seven mediolateral zones three for each hemisphere plus the vermis for regional volume analysis In children with cerebellar malformations decreased total cerebellar volume was associated with delays in global development expressive language cognition as well as gross and fine motor function Decreased volume in the right lateral cerebellar hemisphere was related to impaired cognition expressive language and gross motor function Additionally reduced vermis volume was associated with impaired global development cognition expressive language and gross and fine motor skills as well as behavior problems and a higher rate of positive autism spectrum screening test These results begin to define the structural topography of functional outcome in children with cerebellar malformations and should lead to greater accuracy of prognostication as well as timely early developmental interventionsThis study was supported by the Lifebridge Fund the Caroline Levine Foundation and the Trust Family Foundation MarieEve Bolduc received support from a McGill University Health Centre Research Institute Scholarship Catherine Limperopoulos Canada Research Chair in Brain and Development Tier II is supported by the Canada Research Chairs Program Dr du Plessis is supported through National Institutes of Health grant 1K24NS05756801 We thank Dr Nicol KornerBitensky for her methodological expertise while designing the study and for reviewing the manuscript We also thank Shaye Moore for assistance with manuscript preparation We are very grateful to the children and their families for participating in this study

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Other Papers In This Journal:
  1. Cerebellum: from Fundamentals to Translational Approaches. The Seventh International Symposium of the Society for Research on the Cerebellum
  2. Cerebellar Contribution to Anger Recognition Deficits in Huntington’s Disease
  3. T-Type Calcium Channel as a New Therapeutic Target for Tremor
  4. Compartmentation of the Cerebellar Cortex in the Naked Mole-Rat ( Heterocephalus glaber )
  5. Behavioural Significance of Cerebellar Modules
  6. An fMRI Investigation of Cerebellar Function During Verbal Working Memory in Methadone Maintenance Patients
  7. Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum
  8. Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease
  9. A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder
  10. Spinal Cord Atrophy Correlates with Disability in Friedreich’s Ataxia
  11. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  12. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  13. Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases
  14. Cerebellum and Personality Traits
  15. Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
  16. Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
  17. Increased Catabolic State in Spinocerebellar Ataxia Type 1 Patients
  18. Mild Clinical and Biochemical Phenotype in Two Patients with PMM2-CDG (Congenital Disorder of Glycosylation Ia)
  19. Cerebellar Function in Developmental Dyslexia
  20. Glutamate Dysfunction Associated with Developmental Cerebellar Damage: Relevance to Autism Spectrum Disorders
  21. Non-Ataxic Presenting Symptoms of Dominant Ataxias
  22. Asymmetries in Cerebellar Plasticity and Motor Learning
  23. Clinical Manifestations of Cerebellar Infarction According to Specific Lobular Involvement
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