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Title of Journal: Cerebellum

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Abbravation: The Cerebellum

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Springer US

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DOI

10.1007/bf02221788

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1473-4230

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High Serum GFAP Levels in SCA3/MJD May Not Correla

Authors: Yuting Shi Chunrong Wang Fengzhen Huang Zhao Chen Zhanfang Sun Junling Wang Beisha Tang Tetsuo Ashizawa Thomas Klockgether Hong Jiang
Publish Date: 2015/04/14
Volume: 14, Issue: 6, Pages: 677-681
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Abstract

Spinocerebellar ataxia type 3SCA3 also known as MachadoJoseph disease MJD is the most frequent subtype of autosomal dominant inherited spinocerebellar ataxias which caused by the expansion of CAG repeats in the ATXN3 gene The number of CAG repeats of the abnormal allele determines the rate of disease progression in patients with SCA3/MJD Markers to assess the clinical severity to predict the course of illness and to monitor the efficacy of therapeutic measures can be clinical biological and radiological Here we aimed to explore whether the serum glial fibrillary acidic protein GFAP may act as a biomarker in SCA3/MJD patients and to evaluate the correlation between some markers with the number of CAG repeats in SCA3/MJD patients We showed that the serum levels of GFAP were significantly higher in SCA3/MJD patients than in controls There was a strong positive correlation between the ageadjusted GFAP levels with the number of CAG repeats Ageadjusted International Cooperative Ataxia Rating Scale ICARS scores and Scale for the Assessment and Rating of Ataxia SARA scores correlated with the number of CAG repeats Raw scores and disease durationadjusted GFAP levels ICARS scores and SARA scores were not correlated with the number of CAG repeats Our results reveal novel evidence for the role of the triplet expansion in SCA3/MJDassociated neuronal damageWe are grateful to all subjects for their participation in our study The study was supported by the National Basic Research Program 973 Program Nos 2012CB944601 2012CB517902 2011CB510002 to Hong Jiang National Natural Science Foundation of China Nos 81410308019 81471156 81271260 30971585 30871354 30710303061 and 30400262 to Hong Jiang New Century Excellent Talents in University No NCET100836 to Hong Jiang National Science Foundation of Hunan Province for Distinguished Young Scholars No 14JJ1008 to Hong Jiang Natural Science Foundation of Xinjiang Uygur Autonomous Regions No 2013181014 to Hong Jiang and Undergraduate Innovation Project of Central South University No CY12400 to Hong Jiang

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Other Papers In This Journal:
  1. Cerebellum: from Fundamentals to Translational Approaches. The Seventh International Symposium of the Society for Research on the Cerebellum
  2. Cerebellar Contribution to Anger Recognition Deficits in Huntington’s Disease
  3. T-Type Calcium Channel as a New Therapeutic Target for Tremor
  4. Compartmentation of the Cerebellar Cortex in the Naked Mole-Rat ( Heterocephalus glaber )
  5. Behavioural Significance of Cerebellar Modules
  6. An fMRI Investigation of Cerebellar Function During Verbal Working Memory in Methadone Maintenance Patients
  7. Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum
  8. Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations
  9. Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease
  10. A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder
  11. Spinal Cord Atrophy Correlates with Disability in Friedreich’s Ataxia
  12. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  13. Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases
  14. Cerebellum and Personality Traits
  15. Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
  16. Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
  17. Increased Catabolic State in Spinocerebellar Ataxia Type 1 Patients
  18. Mild Clinical and Biochemical Phenotype in Two Patients with PMM2-CDG (Congenital Disorder of Glycosylation Ia)
  19. Cerebellar Function in Developmental Dyslexia
  20. Glutamate Dysfunction Associated with Developmental Cerebellar Damage: Relevance to Autism Spectrum Disorders
  21. Non-Ataxic Presenting Symptoms of Dominant Ataxias
  22. Asymmetries in Cerebellar Plasticity and Motor Learning
  23. Clinical Manifestations of Cerebellar Infarction According to Specific Lobular Involvement
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