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Title of Journal: Cerebellum

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Abbravation: The Cerebellum

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Springer-Verlag

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DOI

10.1007/bf02193692

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1473-4230

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Spinal Cord Atrophy Correlates with Disability in

Authors: Camila F Chevis Cynthia B da Silva Anelyssa D’Abreu Iscia LopesCendes Fernando Cendes Felipe P G Bergo Marcondes C França
Publish Date: 2012/05/05
Volume: 12, Issue: 1, Pages: 43-47
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Abstract

Although Friedreich’s ataxia is characterized by spinal cord atrophy it remains to be investigated the possible correlation of such atrophy with clinical disability and genetic parameters Thirtythree patients with Friedreich’s ataxia and 30 healthy controls underwent MRI on a 3 T scanner We used T1weighted 3D images to estimate spinal cord area and eccentricity at C2/C3 level based on a semiautomatic image segmentation protocol We quantified severity of ataxia with the Friedreich ataxia rating scale FARS Mean cord area in Friedreich’s ataxia was smaller than in controls 38 vs 679 mm2 p  0001 In contrast mean cord eccentricity was significantly higher in Friedreich’s ataxia when compared to the controls 082 vs 076 p  0001 There was a significant correlation between cord areas and the FARS scores r = −053 p = 0002 Cord damage in Friedreich’s ataxia results in atrophy combined with flattening Cord area is associated to clinical disability and might be useful as a biomarker in the disease

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Other Papers In This Journal:
  1. Cerebellum: from Fundamentals to Translational Approaches. The Seventh International Symposium of the Society for Research on the Cerebellum
  2. Cerebellar Contribution to Anger Recognition Deficits in Huntington’s Disease
  3. T-Type Calcium Channel as a New Therapeutic Target for Tremor
  4. Compartmentation of the Cerebellar Cortex in the Naked Mole-Rat ( Heterocephalus glaber )
  5. Behavioural Significance of Cerebellar Modules
  6. An fMRI Investigation of Cerebellar Function During Verbal Working Memory in Methadone Maintenance Patients
  7. Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum
  8. Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations
  9. Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease
  10. A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder
  11. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  12. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  13. Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases
  14. Cerebellum and Personality Traits
  15. Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
  16. Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
  17. Increased Catabolic State in Spinocerebellar Ataxia Type 1 Patients
  18. Mild Clinical and Biochemical Phenotype in Two Patients with PMM2-CDG (Congenital Disorder of Glycosylation Ia)
  19. Cerebellar Function in Developmental Dyslexia
  20. Glutamate Dysfunction Associated with Developmental Cerebellar Damage: Relevance to Autism Spectrum Disorders
  21. Non-Ataxic Presenting Symptoms of Dominant Ataxias
  22. Asymmetries in Cerebellar Plasticity and Motor Learning
  23. Clinical Manifestations of Cerebellar Infarction According to Specific Lobular Involvement
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