Authors: Heather K Titley Christian Hansel
Publish Date: 2015/01/13
Volume: 15, Issue: 2, Pages: 87-92
Abstract
Synaptic plasticity at the parallel fiber to Purkinje cell synapse has long been considered a cellular correlate for cerebellar motor learning Functionally longterm depression and longterm potentiation at these synapses seem to be the reverse of each other with both pre and postsynaptic expression occurring in both However different cerebellar motor learning paradigms have been shown to be asymmetric and not equally reversible Here we discuss the asymmetric reversibility shown in the vestibuloocular reflex and eyeblink conditioning and suggest that different cellular plasticity mechanisms might be recruited under different conditions leading to unequal reversibility
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