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Title of Journal: Cerebellum

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Abbravation: The Cerebellum

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Springer-Verlag

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DOI

10.1007/s11012-004-6058-7

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1473-4230

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An fMRI Investigation of Cerebellar Function Durin

Authors: Cherie L Marvel Monica L Faulkner Eric C Strain Miriam Z Mintzer John E Desmond
Publish Date: 2011/09/03
Volume: 11, Issue: 1, Pages: 300-310
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Abstract

Working memory is impaired in opioiddependent individuals yet the neural underpinnings of working memory in this population are largely unknown Previous studies in healthy adults have demonstrated that working memory is supported by a network of brain regions that includes a cerebrocerebellar circuit The cerebellum in particular may be important for inner speech mechanisms that assist verbal working memory This study used functional magnetic resonance imaging to examine brain activity associated with working memory in five opioiddependent methadonemaintained patients and five matched healthy controls An item recognition task was administered in two conditions 1 a low working memory load “match” condition in which participants determined whether target letters presented at the beginning of the trial matched a probe item and 2 a high working memory load “manipulation” condition in which participants counted two alphabetical letters forward of each of the targets and determined whether either of these new items matched a probe item Response times and accuracy scores were not significantly different between the groups FMRI analyses indicated that in association with higher working memory load “manipulation” condition the patient group exhibited hyperactivity in the superior and inferior cerebellum and amygdala relative to that of controls At a more liberal statistical threshold patients exhibited hypoactivity in the left prefrontal and medial frontal/preSMA regions These results indicate that verbal working memory in opioiddependent individuals involves a disrupted cerebrocerebellar circuit and shed light on the neuroanatomical basis of working memory impairments in this populationThe authors would like to thank Jonathan Cooper for his assistance with scoring the data MRI scans were obtained at the Kirby Center of the Kennedy Krieger Institute in Baltimore MD Parts of this research were presented at the Society for Neuroscience Annual Meeting 2009 and Organization for Human Brain Mapping Annual Meeting 2011 Funding for this study was provided by NIH grants K01 DA030442 Marvel K24 DA023186 Strain R01 MH060234 Desmond and the Nellie Ball Research Trust Marvel

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Other Papers In This Journal:
  1. Cerebellum: from Fundamentals to Translational Approaches. The Seventh International Symposium of the Society for Research on the Cerebellum
  2. Cerebellar Contribution to Anger Recognition Deficits in Huntington’s Disease
  3. T-Type Calcium Channel as a New Therapeutic Target for Tremor
  4. Compartmentation of the Cerebellar Cortex in the Naked Mole-Rat ( Heterocephalus glaber )
  5. Behavioural Significance of Cerebellar Modules
  6. Neurofilament Heavy Chain Expression Reveals a Unique Parasagittal Stripe Topography in the Mouse Cerebellum
  7. Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations
  8. Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease
  9. A Cerebellar Framework for Predictive Coding and Homeostatic Regulation in Depressive Disorder
  10. Spinal Cord Atrophy Correlates with Disability in Friedreich’s Ataxia
  11. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  12. High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression
  13. Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases
  14. Cerebellum and Personality Traits
  15. Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
  16. Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus
  17. Increased Catabolic State in Spinocerebellar Ataxia Type 1 Patients
  18. Mild Clinical and Biochemical Phenotype in Two Patients with PMM2-CDG (Congenital Disorder of Glycosylation Ia)
  19. Cerebellar Function in Developmental Dyslexia
  20. Glutamate Dysfunction Associated with Developmental Cerebellar Damage: Relevance to Autism Spectrum Disorders
  21. Non-Ataxic Presenting Symptoms of Dominant Ataxias
  22. Asymmetries in Cerebellar Plasticity and Motor Learning
  23. Clinical Manifestations of Cerebellar Infarction According to Specific Lobular Involvement
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