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Title of Journal: Knee Surg Sports Traumatol Arthrosc

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Abbravation: Knee Surgery, Sports Traumatology, Arthroscopy

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Springer-Verlag

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1433-7347

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Cellfree collagen type I matrix for repair of car

Authors: Turgay Efe Christina Theisen Susanne FuchsWinkelmann Thomas Stein Alan Getgood Marga B Rominger Jürgen R J Paletta Markus D Schofer
Publish Date: 2011/11/18
Volume: 20, Issue: 10, Pages: 1915-1922
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Abstract

Several welldescribed techniques are available for the treatment of chondral and osteochondral defects The aim of the study was to assess the efficacy of a singlestage procedure incorporating a new cellfree collagen type I gel for the treatment of small chondral and osteochondral defects in the knee evaluated at 2year followupFifteen patients were treated with a cellfree collagen type I gel matrix of 11 mm diameter The grafts were implanted in the debrided cartilage defect and fixed by pressfit only The clinical outcome was assessed preoperatively and at 6 weeks and 6 12 and 24 months after surgery using the International Knee Documentation Committee IKDC score Tegner activity scale and visual analogue scale VAS Graft attachment rate was assessed 6 weeks postoperatively using magnetic resonance imaging MRI Cartilage regeneration was evaluated using the Magnetic Observation of Cartilage Repair Tissue MOCART score at 6 12 and 24 months after implantation Clinical results were correlated with MRI findingsSix male and nine female patients were included in this study with a mean age of 26 range 19–40 No complications were reported The mean VAS values after 6 weeks and the mean IKDC patient values after 6 months were significantly improved from the preoperative values P = 0005 and P = 0009 respectively This improvement remained up to the latest followup There were no significant differences between the median preoperative and postoperative Tegner values ns Significant improvement of the mean MOCART score was observed after 12 months and remained by 24 months P  0001 MR images showed that in 14 of the 15 patients the graft was completely attached by 6 weeks postoperatively At 24 months after implantation MRI demonstrated complete filling in all cases with a mainly smooth surface complete integration of the border zone homogenous structure of the repaired tissue and nearly normal signal intensity No correlation between any variables of the MOCART score and the clinical scores was observed

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