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Title of Journal: Knee Surg Sports Traumatol Arthrosc

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Abbravation: Knee Surgery, Sports Traumatology, Arthroscopy

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Publisher

Springer Berlin Heidelberg

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DOI

10.1007/bf00559766

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ISSN

1433-7347

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Influence of TNFα and biomechanical stress on mat

Authors: Yanjun Zhang Wei Huang Jiahuang Jiang Jing Xie Chunmin Xu Chunli Wang Lin Yin Li Yang Kevin Zhou Peter Chen KL Paul Sung
Publish Date: 2013/02/02
Volume: 22, Issue: 9, Pages: 1997-2006
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Abstract

It was reported that not only ACL but also the synovium may be the major regulator of matrix metalloproteinases MMPs in synovial fluids after ACL injury In order to further confirm whether synovium is capable of regulating the microenvironment in the process of ACL injury the complicated microenvironment of joint cavity after ACL injury was mimicked and the combined effects of mechanical injury and inflammatory factor tumour necrosis factorα TNFα on expressions of lysyl oxidases LOXs and MMPs in synovial fibroblasts derived from normal human synovium were studiedHuman normal knee joint synovial fibroblasts were stimulated for 1–6 h with mechanical stretch and inflammatory factor TNFα Total RNA was harvested reverse transcribed and assessed by realtime polymerase chain reaction for the expression of LOXs and MMP1 2 3 messenger RNAs MMP2 activity was assayed from the collected culture media samples using zymographyCompared to control group our results showed that 6  physiological stretch increased MMP2 and LOXs except LOXL3 decreased MMP1 and MMP3 injurious stretch 12  decreased LOXs except LOXL2and increased MMP1 2 and 3 the combination of injurious stretch and TNFα decreased LOXs and increased MMP1 2 and 3 in synovial fibroblasts in a synergistical mannerThis study demonstrated that combination of mechanical injury and inflammatory factors upregulated the expressions of MMPs and downregulated the expressions of LOXs in synovial fibroblasts eventually alter the balance of tissue healing Thus synovium may be involved in regulating the microenvironment of joint cavity Based on the mechanism early interventions to inhibit the production of MMPs or promote the production of LOXs in the synovial fibroblasts should be performed to facilitate the healing of tissueThis study was supported by the Innovation and Attracting Talents Program for College and University “111” Project B06023 NSF Projects 10672195 30870607 CSTC2008BB5192 Sharing fund of Chongqing university’s largescale equipment 2009063038 and by NIH AR45635 USA

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