The effects of repeated intraarticular PRP inject

Authors: Alberto Gobbi Dnyanesh Lad Georgios Karnatzikos

Publish Date: 2014/04/20

Volume: 23, Issue: 8, Pages: 2170-2177

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Abstract

This is a prospective randomized study in which 93 patients 119 knees were followed up for a minimum of 2 years Fifty knees were randomly selected prior to the first injection to receive a second cycle at the completion of 1 year A cycle consisted of three injections each given at a monthly interval The outcome was assessed using Knee Injury and Osteoarthritis Outcome Score KOOS Visual Analogue Scale VAS Tegner and Marx scoring systems recorded prior to the first injection and then at 12 18 and 24 monthsThere was a significant improvement in all scores over time compared to the pretreatment value p  0001 At 12 months both groups showed similar and significant improvement At 18 months except for KOOS Symptoms and Tegner score all other parameters showed a significant difference between the two groups in favour of the patients who had received the second cycle p  0001 At 2 years the scores declined in both groups but remained above the pretreatment value with no significant difference between the groups despite the patients with two cycles showing higher mean values for all the scoresIntraarticular PRP injections into the knee for symptomatic early stages of OA are a valid treatment option There is a significant reduction in pain and improvement in function after 12 months which can be further improved at 18 months by annual repetition of the treatment Although the beneficial effects are ill sustained at 2 years the results are encouraging when compared to the pretreatment function

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