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Journal Title
Title of Journal: Knee Surg Sports Traumatol Arthrosc
Abbravation: Knee Surgery, Sports Traumatology, Arthroscopy
Publisher
Springer Berlin Heidelberg
DOI
10.1016/0026-0576(95)90261-9
ISSN
1433-7347
Sixty patients affected by primary knee osteoarthritis and candidates to receive a primary unilateral total knee arthroplasty were enrolled in a prospective randomized controlled study Exclusion criteria were the following tranexamic acid allergy the use of pharmacological anticoagulant therapy previous knee surgery and renal failure For each patient the following parameters were investigated the blood loss volume the haemoglobin and haematocrit concentrations and the blood transfusion needsCompared to the control group the administration of systemic tranexamic acid significantly reduces p 005 both the blood loss average reduction 398 and the blood transfusion needs 64 Furthermore the tranexamic acid group shows a significant reduction p 005 compared to the knee flexion group of the blood loss average reduction 318 and the transfusion needs 65 However even if the knee flexion technique slightly reduces the blood loss average reduction 116 compared to the control group this difference is not statistically significant ns Moreover this treatment did not reduce the transfusion needs compared to the control group ns Incidence of complications was not influenced by any of the treatments