Authors: Jeff Grant Vu Tran Sanjoy K Bhattacharya Laura Bianchi
Publish Date: 2012/11/08
Volume: 246, Issue: 2, Pages: 167-175
Abstract
Increasing evidence suggests that trabecular meshwork TM cells participate in the regulation of intraocular pressure by controlling the rate of filtration of the aqueous humor Ionic conductances that regulate cell volume and shape have been suggested to play an important role in TM cell volume regulation Here we compared ionic currents from TM cells derived from a normal subject CTM and from an individual affected by glaucoma GTM We found that while the ionic current types were similar the current amplitudes and percentage of cells endowed with specific current at baseline were different in the two cell lines Thus we found that the majority of CTM cells were endowed with a swellingactivated Cl− current at baseline whereas in the majority of GTM cells this current was not active at baseline and became activated only after perfusion with a hypotonic solution An inward rectifier K+ current was also more prevalent in CTM than in GTM cells Our work suggests that disregulation of one or more of these ionic currents may be at the basis of TM cell participation in the development of glaucoma
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