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Title of Journal: J Membrane Biol

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Abbravation: The Journal of Membrane Biology

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Springer US

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DOI

10.1016/0191-6599(93)90022-I

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1432-1424

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Effects of Phospholipase ASubscript2/Subscript

Authors: Mikhail V Dubinin Maxim E Astashev Nikita V Penkov Sergey V Gudkov Igor A Dyachenko Victor N Samartsev Konstantin N Belosludtsev
Publish Date: 2016/01/13
Volume: 249, Issue: 3, Pages: 339-347
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Abstract

The work examines the effect of inhibitors of cytosolic Ca2+dependent and Ca2+independent phospholipases A2 on bilayer lipid membranes It was established that trifluoroperazine TFP and to a lesser extent arachidonyl trifluoromethyl ketone AACOCF3 and palmitoyl trifluoromethyl ketone PACOCF3 were able to permeabilize artificial lipid membranes BLM and liposomes It was shown that AACOCF3 lowered the temperature of phase transition of DMPC liposomes inducing disordering of the hydrophobic region of lipid bilayer TFP disordered membranes both in the hydrophobic region and in the region of hydrophilic heads this being accompanied by changes in the membrane permeability appearance of a channellike BLM activity and leakage of sulforhodamine B from liposomes In contrast to AACOCF3 and TFP PACOCF3 increased membrane orderliness in the hydrophobic region heightened the temperature of phase transition of DMPC liposomes and in the region of lipid heads The effectiveness of AACOCF3 and PACOCF3 as inductors of BLM and liposome permeabilization was considerably lower comparatively to TFP As revealed by dynamic light scattering incorporation of TFP AACOCF3 and PACOCF3 into the membrane of liposomes resulted in the increase of the average size of particles in the suspension presumably due to their aggregation or fusion The paper discusses possible mechanisms of the influence of phospholipase A2 inhibitors on bilayer lipid membranes

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  2. Gating-Related Molecular Motions in the Extracellular Domain of the I Ks Channel: Implications for I Ks Channelopathy
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  10. Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells
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