Authors: Subhabrata Kar Priyanka Bajaj Rajan K Tripathy Abhay H Pande
Publish Date: 2013/05/15
Volume: 246, Issue: 6, Pages: 443-452
Abstract
Oxidative modification of phospholipids generates a variety of oxidized phospholipid OxPL species which differ considerably in their chemical compositions and molecular structures Recent results suggest that even closely related OxPL species can have considerably different biological effects However the molecular mechanism for this is not yet clear In truncated OxPLs tOxPLs the fatty acyl chain is shorter in length than the parent nonoxidized phospholipid molecules and contains a polar functional groups In a previous study we showed that two closely related tOxPL species having a similar polar functional group and differing only in the length of the oxidized fatty acyl chain exerts significantly different effects on the physicochemical properties of the nonoxidized phospholipid particles containing these lipids Kar et al Chem Phys Lipids 16454–61 2011 In this study we have characterized the effect of polar functional groups of oxidized fatty acyl chain on the physicochemical properties of the nonoxidized phospholipid particles containing these lipids Our results show that OxPL species differing only in the chemical nature of polar functional groups in their oxidized fatty acyl chain modify the properties of nonoxidized phospholipid particles containing them in a distinctive way These results indicate that different species of OxPLs induce unique changes in the physicochemical properties of lipid particles/membranes containing them and that this may lead to their different biological effects
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