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Title of Journal: J Membrane Biol

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Abbravation: The Journal of Membrane Biology

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Springer US

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DOI

10.1002/pbc.24626

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1432-1424

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Inactivation of Emphasis Type="Italic"Pseudomona

Authors: Wolfgang Frey Christian Gusbeth Thomas Schwartz
Publish Date: 2013/05/10
Volume: 246, Issue: 10, Pages: 769-781
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Abstract

An important issue for an economic application of the pulsed electric field treatment for bacterial decontamination of wastewater is the specific treatment energy needed for effective reduction of bacterial populations The present experimental study performed in a field amplitude range of 40  E  200 kV/cm and for a suspension conductivity of 001 = κ e  02 S/m focusses on the application of short pulses 25 ns  T  10 μs of rectangular bipolar and exponential shape and was made on Pseudomonas putida which is a typical and widespread wastewater microorganism The comparison of inactivation results with calculations of the temporal and azimuthal membrane charging dynamics using the model of Pauly and Schwan revealed that for efficient inactivation membrane segments at the cell equator have to be charged quickly and to a sufficiently high value on the order of 05 V After fulfilling this basic condition by an appropriate choice of pulse field strength and duration the log rate of inactivation for a given suspension conductivity of 02 S/m was found to be independent of the duration of individual pulses for constant treatment energy expenditure Moreover experimental results suggest that even pulse shape plays a minor role in inactivation efficiency The variation of the suspension conductivity resulted in comparable inactivation performance of identical pulse parameters if the product of pulse duration and number of pulses was the same ie required treatment energy can be linearly downscaled for lower conductivities provided that pulse amplitude and duration are selected for entire membrane surface permeabilizationThe authors acknowledge the efforts of Silke Kirchen and SilkeMareike Marten for CFU analysis the help of Rüdiger Wüstner in preparing and performing the pulse experiments and the detailed discussions of Aude Silve on membrane charging The authors appreciate the helpful scientific discussions on bacterial inactivation within the framework of COST TD1104 This study was funded by BMBF grant 02WT0675 administered by the Karlsruhe Institute of Technology


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  1. The Chemical Nature of the Polar Functional Group of Oxidized Acyl Chain Uniquely Modifies the Physicochemical Properties of Oxidized Phospholipid-Containing Lipid Particles
  2. Gating-Related Molecular Motions in the Extracellular Domain of the I Ks Channel: Implications for I Ks Channelopathy
  3. Effects of Phospholipase A 2 Inhibitors on Bilayer Lipid Membranes
  4. The Effect of Millisecond Pulsed Electric Fields (msPEF) on Intracellular Drug Transport with Negatively Charged Large Nanocarriers Made of Solid Lipid Nanoparticles (SLN): In Vitro Study
  5. Evolution of the Oligopeptide Transporter Family
  6. Slow Gating of Gap Junction Channels and Calmodulin
  7. Molecular Dynamic Simulation of Transmembrane Pore Growth
  8. Genistein Modifies the Activation Kinetics and Magnitude of Phosphorylated Wild-Type and G551D-CFTR Chloride Currents
  9. A Multi-label Classifier for Prediction Membrane Protein Functional Types in Animal
  10. Extracellular Adenine Nucleotides Regulate Na+/H+ Exchanger NHE3 Activity in A6-NHE3 Transfectants by a cAMP/PKA-dependent Mechanism
  11. Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells
  12. Part-2: Analytical Expressions of Concentrations of Glucose, Oxygen, and Gluconic Acid in a Composite Membrane for Closed-Loop Insulin Delivery for the Non-steady State Conditions
  13. Prediction of Protein–Protein Interaction Sites with Machine-Learning-Based Data-Cleaning and Post-Filtering Procedures
  14. Salinity-Induced Noise in Membrane Potential of Characeae Chara australis : Effect of Exogenous Melatonin
  15. Swelling-Induced Ca 2+ Influx and K + Efflux in American Alligator Erythrocytes
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