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Title of Journal: J Membrane Biol

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Abbravation: The Journal of Membrane Biology

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Springer-Verlag

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DOI

10.1007/978-3-319-33210-9_7

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1432-1424

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Genistein Modifies the Activation Kinetics and Mag

Authors: L BulteauPignoux R Dérand T Métayé M Joffre F Becq
Publish Date: 2014/03/18
Volume: 188, Issue: 3, Pages: 175-182
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Abstract

We have studied the mechanism by which genistein activates cystic fibrosis transmembrane conductance regulator CFTR in CHO cells expressing wild type or G551DCFTR In wildtype CHO cells after exposure to 25 mM forskolin 25 mM genistein induced a further 2fold and rapid increase of the forskolinactivated CFTR current In both types of cells when forskolin was added after genistein preincubation wholecell current density was greatly reduced compared to that measured when genistein was added after phosphorylation of CFTR and all activation kinetic parameters were significantly altered Genistein had no effect on the adenylate cyclase activity Our results suggest that the occupancy of a putative genistein binding site is critical for the gating mechanism of CFTR chloride channels which depending on the phosphorylation status of the Rdomain drives CFTR either into a refractory state or alternatively to a highly activated state

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  1. The Chemical Nature of the Polar Functional Group of Oxidized Acyl Chain Uniquely Modifies the Physicochemical Properties of Oxidized Phospholipid-Containing Lipid Particles
  2. Gating-Related Molecular Motions in the Extracellular Domain of the I Ks Channel: Implications for I Ks Channelopathy
  3. Effects of Phospholipase A 2 Inhibitors on Bilayer Lipid Membranes
  4. The Effect of Millisecond Pulsed Electric Fields (msPEF) on Intracellular Drug Transport with Negatively Charged Large Nanocarriers Made of Solid Lipid Nanoparticles (SLN): In Vitro Study
  5. Evolution of the Oligopeptide Transporter Family
  6. Slow Gating of Gap Junction Channels and Calmodulin
  7. Molecular Dynamic Simulation of Transmembrane Pore Growth
  8. A Multi-label Classifier for Prediction Membrane Protein Functional Types in Animal
  9. Extracellular Adenine Nucleotides Regulate Na+/H+ Exchanger NHE3 Activity in A6-NHE3 Transfectants by a cAMP/PKA-dependent Mechanism
  10. Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells
  11. Part-2: Analytical Expressions of Concentrations of Glucose, Oxygen, and Gluconic Acid in a Composite Membrane for Closed-Loop Insulin Delivery for the Non-steady State Conditions
  12. Prediction of Protein–Protein Interaction Sites with Machine-Learning-Based Data-Cleaning and Post-Filtering Procedures
  13. Salinity-Induced Noise in Membrane Potential of Characeae Chara australis : Effect of Exogenous Melatonin
  14. Swelling-Induced Ca 2+ Influx and K + Efflux in American Alligator Erythrocytes
  15. Tubular Fluid Secretion in the Seminiferous Epithelium: Ion Transporters and Aquaporins in Sertoli Cells
  16. Ionic Currents of Human Trabecular Meshwork Cells from Control and Glaucoma Subjects
  17. Inactivation of Pseudomonas putida by Pulsed Electric Field Treatment: A Study on the Correlation of Treatment Parameters and Inactivation Efficiency in the Short-Pulse Range
  18. Effect of Chloride Channel Inhibitors on Cytosolic Ca 2+ Levels and Ca 2+ -Activated K + (Gardos) Channel Activity in Human Red Blood Cells
  19. Carbon Nanotube-Encapsulated Drug Penetration Through the Cell Membrane: An Investigation Based on Steered Molecular Dynamics Simulation
  20. Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices
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