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Title of Journal: Pharm Chem J

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Abbravation: Pharmaceutical Chemistry Journal

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Publisher

Springer US

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DOI

10.1007/bf02140960

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ISSN

1573-9031

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Synthesis and Antioxidant Activity of Securinine D

Authors: S G Klochkov M E Neganova S V Afanas’eva E F Shevtsova
Publish Date: 2014/05/15
Volume: 48, Issue: 1, Pages: 15-17
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Abstract

A series of 9amino14oxa7azatetracyclo6610111027pentadeca11en13ones were synthesized The starting material was the natural alkaloid securinine which underwent a Michael reaction with pharmacophoric tryptamines and substituted piperazines The structure and stereochemistry of the previously unknown adduct with 5methoxytryptamine were established using twodimensional NMR experiments COSY and NOESY The biological activity of the synthesized securinine aminoderivatives was investigated It was shown that several of the synthesized securinine conjugates exhibited antioxidant and ironchelating activity and were interesting for further studies as potential pharmacologically active compounds

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  2. Antifungal Activity of the Extractives of Coleus Forskohlii Roots and Forskolin
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  5. Pharmacological activity of ziacryl, a zinc salt of polyacrylic acid
  6. Characteristics of Assessments of the Sterility of Various Groups of Solid Drug Formulations for Parenteral Administration
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  8. Synthesis and Antibacterial Activity of 5-Thiomethylfuran-2-Carboxylic Acid Derivatives
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