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Title of Journal: Pharm Chem J

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Abbravation: Pharmaceutical Chemistry Journal

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Springer US

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DOI

10.1002/zaac.201000093

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ISSN

1573-9031

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Comparative Study of Polycomplexes Based on Carbop

Authors: R I Mustafin I I Semina V R Garipova A V Bukhovets A Yu Sitenkov A R Salakhova C G M Gennari F Cilurzo
Publish Date: 2015/05/01
Volume: 49, Issue: 1, Pages: 1-6
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Abstract

We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes IPEC in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits The study IPEC were prepared using different grades of Carbopol® polymer C71g C2020 and Noveon® AA1 and oppositely charged polyelectrolytes – Eudragit® EPO or the natural polysaccharide lowviscosity chitosan These studies demonstrated the potential for IPEC samples based on Carbopol® as a new modifiedrelease drug delivery system At the same time assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier

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