Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Pharm Chem J

Search In Journal Title:

Abbravation: Pharmaceutical Chemistry Journal

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1002/ejlt.201200056

Search In DOI:

ISSN

1573-9031

Search In ISSN:
Search In Title Of Papers:

Properties of the Novel Photosensitizer βββ′β′

Authors: A P Lastovoi A A Ignatova A V Feofanov E A Machinskaya V I IvanovaRadkevich
Publish Date: 2014/06/14
Volume: 48, Issue: 2, Pages: 77-81
PDF Link

Abstract

The abilities of solubilizers Cremophor EL Tween 80 Emuxol 3 and Pluronic F68 to deliver the novel promising photosensitizer βββ′β′tetramethyltribenzotetraazachlorin H2TBTAC into A549 human lung adenocarcinoma cells in vitro were compared It was found that the number of H2TBTAC monomers in the solubilizer solutions correlated with the amount of fluorescent monomer accumulated in the cells The H2TBTAC monomer showed significantly higher ability to generate singlet oxygen than H2TBTAC aggregates It was established that Cremophor EL provided the maximum amount of H2TBTAC monomers in solution and the best stability during storage of the composition Cremophor EL improved the accumulation of H2TBTAC monomer in A549 cell cytoplasm reaching saturation after incubation for 2 h and gave the maximum H2TBTAC accumulation coefficient 07 ± 01 Experiments in vivo showed therapeutically significant antineoplastic activity for photodynamic therapy with H2TBTAC stabilized in Cremophor EL solution 10

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Composition of biologically active substances isolated from the fruits of Russian olive ( Elaeagnus angustifolia ) introduced in the European part of Russia
  2. Antifungal Activity of the Extractives of Coleus Forskohlii Roots and Forskolin
  3. Improvement of methodological approaches to the standardization of medicines in the pharmaceutical dosage form of tablets
  4. Synthesis and Antioxidant Activity of Securinine Derivatives
  5. Pharmacological activity of ziacryl, a zinc salt of polyacrylic acid
  6. Characteristics of Assessments of the Sterility of Various Groups of Solid Drug Formulations for Parenteral Administration
  7. Chemical Constituents of Rabdosia japonica var. glaucocalyx
  8. Synthesis and Antibacterial Activity of 5-Thiomethylfuran-2-Carboxylic Acid Derivatives
  9. Drug synthesis methods and manufacturing technology
  10. Synthesis of 4-Aryl(Hetaryl)Spinaceamine Thioureas
  11. 18 F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)
  12. Studies of Nitrate Accumulation in Fresh Echinacea Purpurea Herb and Its Processed Products
  13. Developing analytical techniques for GB-115 determination in solid dosage form (tablets)
  14. Developing analytical methods for the creation of the state reference sample of noopept
  15. Comparative Study of Polycomplexes Based on Carbopol ® and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System
  16. Standardization of inulin extracted from Dahlia single tubers and some physicochemical properties of inulin
  17. Synthesis and antibacterial activity of 4-(2-r-vinyl) derivatives of functionally substituted 2,5-dihydrofurans
  18. XXI Century: How Our Notions About Liposomal Drugs Have Been Transformed
  19. Interaction of Afobazole with Sigma-1 Receptors in the Mouse Brain
  20. Synthesis and Cytotoxic Activity of Ethyl 2-Amino-1-Benzamido-4-Oxo-5-(2-Oxo-2-Arylethylidene)- 4,5-Dihydro-1 H -Pyrrole-3-Carboxylates
  21. Ultrafiltration-Based Extraction and HPLC Analysis of Naproxen Sodium in Human Plasma Samples: an Innovative Approach to Pharmaceutical Analysis
Search Result: