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Title of Journal: Pharm Chem J

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Abbravation: Pharmaceutical Chemistry Journal

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Springer US

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DOI

10.1007/s10393-010-0304-3

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ISSN

1573-9031

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Interaction of Afobazole with Sigma1 Receptors in

Authors: E V Abramova M V Voronin S B Seredenin
Publish Date: 2015/05/01
Volume: 49, Issue: 1, Pages: 7-9
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Abstract

Radioligand analysis was used to study the interaction between afobazole and sigma1 receptors Sigmar1 in the brains of inbred C57B1/6 BALB/c and mongrel CD1 mice Afobazole binding sites were found to be identical to those of the prototype Sigmar1 agonists +pentazocine and PRE084 Depending on the structure of the prototype ligand and the in vitro incubation conditions the specific binding of afobazole with Sigmar1 in brain homogenates from inbred mice was characterized by different receptor interaction models In competitive displacement of G3HPRE084 the affinity of Sigmar1 for afobazole in BALB/c mice was significantly greater than that in C57B1/6 and CD1 mice

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  2. Antifungal Activity of the Extractives of Coleus Forskohlii Roots and Forskolin
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  6. Pharmacological activity of ziacryl, a zinc salt of polyacrylic acid
  7. Characteristics of Assessments of the Sterility of Various Groups of Solid Drug Formulations for Parenteral Administration
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  16. Comparative Study of Polycomplexes Based on Carbopol ® and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System
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