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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1002/3527608761.ch7

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1435-232X

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Isolation of human chromosome 21specific cosmids

Authors: DeXing Hou Haruo Kishida Takanori Shimokawa Eiichi Soeda
Publish Date: 1994/12
Volume: 39, Issue: 4, Pages: 411-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptA cosmid library of 3×105 clones has been constructed from a human x hamster hybrid cell line 153E9a3 which contains human chromosome 21 HC21 as the only human chromosome From 56500 clones of this library 229 HC21specific cosmids have been isolated by their hybridization to total human DNA and by their failure to hybridize to total Chinese hamster DNA The cosmids isolated were then characterized of these 28 cosmids 122 of those tested contained Not1 sites and 41 cosmids were localized on the eight subregions of HC21 by differential hybridization with AluPCR products obtained from a hybrid mapping panel The cosmids localized were further integrated into the existing contigs using the endspecific probes of the clone insert Therefore they provided useful anchor points for contig mapping and walking

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  2. Mitochondrial DNA mutations in Leigh syndrome and their phylogenetic implications
  3. Distal 15q trisomy with Dandy-Walker malformation in a female infant
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  6. Mucopolysaccharidosis IVA: A novel splice acceptor site mutation in intron 4 of the N -acetylgalactosamine-6-sulfate sulfatase gene in an afghanistan girl with classical morquio disease
  7. Genetic alteration of the DCX gene in Japanese patients with subcortical laminar heterotopia or isolated lissencephaly sequence
  8. Novel polymorphism in the 5′-untranslated region of the interleukin-4 gene
  9. A comprehensive method to scan for point mutations of the glucose 6 phosphate dehydrogenase gene
  10. Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non- APOE -ε4 carriers
  11. A linkage disequilibrium at the candidate gene locus for 16q-linked autosomal dominant cerebellar ataxia type III in Japan
  12. The hOGG1 Ser 326 Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance
  13. Concordance and discordance of anencephaly in 109 twin pairs in Japan
  14. Molecular cloning of a novel human gene ( SIRP-B2 ) which encodes a new member of the SIRP/SHPS-1 protein family
  15. Genomic imprinting and its relevance to genetic diseases
  16. No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population
  17. Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan
  18. Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement
  19. Cancer-predisposing genes and chromosome mutation
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  21. Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples
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  24. Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes
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  27. A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia
  28. Molecular basis of intermittent maple syrup urine disease: novel mutations in the E2 gene of the branched-chain α-keto acid dehydrogenase complex
  29. Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects
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