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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1016/0167-4889(82)90045-3

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1435-232X

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Subsequent pregnancy outcomes in recurrent miscarr

Authors: Mayumi SugiuraOgasawara Koji Aoki Tomoyuki Fujii Tomio Fujita Rie Kawaguchi Tetsuo Maruyama Nobuaki Ozawa Toshitaka Sugi Toshiyuki Takeshita Shigeru Saito
Publish Date: 2008/07
Volume: 53, Issue: 7, Pages: 622-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptInformation concerning the prognosis of subsequent pregnancies in patients with reciprocal translocations is limited This study was performed to determine the percentage success rate with first pregnancies after ascertainment of a carrier status A total of 2382 couples with a history of two or more consecutive miscarriages were studied in multicenters The prevalence of an abnormal chromosome in either partner was examined and subsequent success rates were compared between cases with and without an abnormal karyotype in either partner A total of 129 couples 54 had an abnormal karyotype in one partner excluding inversion 9 in 44 men and in 85 women Thus 2253 couples had a normal karyotype in both partner Eightyfive 36 had translocations 13 being Robertsonian translocations Twentynine of the 46 cases 630 who became pregnant with reciprocal translocations in either partner experienced a live birth with natural conception In contrast 950 of 1207 cases 787 with normal chromosomes had successful live births the difference being significant P = 0019 No infant with an unbalanced translocation was found in 29 cases of successful pregnancy following recurrent miscarriage Pregnancy prognosis was worsened with either maternal or paternal reciprocal translocations Explanation of the success rate with natural conception should be provided before the subsequent pregnancy after ascertainment of carrier status

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