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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1016/0022-5193(68)90126-4

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1435-232X

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High heritability of bone size at the hip and spin

Authors: WeiXia Jian JiRong Long HongWen Deng
Publish Date: 2004/02
Volume: 49, Issue: 2, Pages: 87-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptBone size an independent determinant of bone strength is an important risk factor for osteoporotic fracture In the present study we investigated the magnitude of the genetic determination of bone size at the spine and hip and their genetic covariation if any in a population of Chinese residing in Shanghai City of PR China The subjects were 50 healthy fullsib pairs of females 188 motherdaughter pairs and 128 husbandwife pairs selected from 401 nuclear families Bone size centimeters squared was measured at the spine and hip by dualenergy Xray absorptiometry DEXA The narrowsense heritabilities h2 SE of bone size at the spine and hip were 063 014 and 045 014 respectively when estimated by fullsib pairs and 060 007 and 069 007 respectively when estimated by motherdaughter pairs Marginally significant genetic correlation was observed between the spine and hip bone size The significantly and moderately high h2 values for bone size demonstrated in this study warrant a subsequent genetic study to search for the genes or genomic regions underlying the phenotype in Chinese

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