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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1002/chin.201040131

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1435-232X

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The ihOGG1/i Sersup326/supCys gene polymor

Authors: ChiaoLing Wang MingChia Hsieh ShihChieh Hsin HsingYi Lin KunDer Lin ChaoSheng Lo ZhaoHong Chen ShyiJang Shin
Publish Date: 2006/02
Volume: 51, Issue: 2, Pages: 124-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptIncreased oxidative stress has been observed to contribute the development of insulin resistance Oxidative stress is known to increase the conversion of deoxyguanosine dG to 8hydroxy2′deoxyguanosine 8OHdG Human 8oxoguanine glycosylase hOGG1 is the key component responsible for the removal of 8OHdG from oxidatively damaged DNA The repair activity of the hOGG1 Ser326Cys gene variant has been demonstrated to be lower than that of the hOGG1 Ser/Ser genotype Therefore the possible association of the hOGG1 Ser326Cys gene variant with insulin sensitivity was investigated in 279 normal glucosetolerant subjects without history of cancer Allele frequency was 215 for the Ser/Ser genotype n=60 459 for the Ser/Cys genotype n=128 and 326 for the Cys/Cys genotype n=91 Subjects carrying the Cys/Cys genotype had significantly lower insulin sensitivity levels assessed by homeostasis model assessmentinsulin resistance HOMAIR compared with the Ser/Ser and Ser/Cys genotypes P0001 and P0001 respectively In a multiple linear regression analysis the Cys/Cys genotype was a significant determinant of HOMAIR independent of age sex body mass index fasting plasma cholesterol triglyceride HDL cholesterol LDL cholesterol or hypertension The present study indicates that the hOGG1 gene Cys/Cys variant is associated with a significant decrease in insulin sensitivity in subjects with normal glucose tolerance

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