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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1007/bf00320317

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1435-232X

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Ret/PTC3 is the most frequent form of gene rearran

Authors: Yutaka Kitamura Kaori Minobe Tomoko Nakata Kazuo Shimizu Shigeo Tanaka Minoru Fujimori Shiro Yokoyama Koichi Ito Masahiko Onda Mitsuru Emi
Publish Date: 1999/03
Volume: 44, Issue: 2, Pages: 96-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptRearrangements of the RET and TRK protooncogenes which generate fusion oncogenes are frequent in papillary thyroid carcinomas in Caucasian populations To determine the spectrum of gene rearrangements in Japanese patients we systematically examined 40 papillary thyroid carcinomas for all possible types of gene fusion events involving RET or TRK genes RET rearrangements were found in ten tumors 25 ret/PTC1 had occurred in two tumors ret/PTC2 in one ret/PTC3 in six and a novel RET rearrangement in the remaining patient In this last patient the 5′ novel sequence was fused inframe to the RET amino acid sequence thus the fusion gene may encode a protein with a RET kinase domain at the carboxy terminus The RET gene was fused to 5′ donor sequences at the beginning of exon 12 in all ten tumors No rearrangements involving the TRK gene were found in this panel of carcinomas Our results indicated that constitutive activation of the RET by gene rearrangement is a frequent mechanism of papillary thyroid carcinogenesis in Japanese adults

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