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Abbravation: Journal of Human Genetics

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Nature Publishing Group

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10.1002/2015WR018427

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1435-232X

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In situ detection of insulinlike growth factor II

Authors: Tetsuro Sohda Kaoru Iwata Hidenobu Soejima Seiichiro Kamimura Hiroshi Shijo Kankatsu Yun
Publish Date: 1998/02
Volume: 43, Issue: 1, Pages: 49-
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Abstract

Thank you for visiting naturecom You are using a browser version with limited support for CSS To obtain the best experience we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer In the meantime to ensure continued support we are displaying the site without styles and JavaScriptTo assess the relationship between insulinlike growth factor II IGF2 and H19 gene expression at the cellular level we have examined the distribution of IGF2 and H19 mRNA by means of in situ hybridization in hepatic malignancies consisting of hepatocellular carcinoma HCC cholangiocellular carcinoma CCC and metastatic liver cancer MLC In HCC 15 of 27 tumors 56 and 11 of 27 tumors 41 demonstrated increased IGF2 and H19 gene expression respectively Of 16 HCCs with increased expression of either IGF2 or H19 10 tumors coexpressed both transcripts at comparable levels Moreover the spatiotemporal distribution and the cellular localization of the two gene transcripts were almost identical suggesting the presence of a reciprocal relation between IGF2 and H19 In addition 5 HCCs showed increased IGF2 expression without concomitant H19 expression whereas 1 HCC showed increased H19 expression without IGF2 transcripts However 11 HCCs showed no IGF2 or H19 expression On the other hand neither IGF2 transcripts nor H19 transcripts were detected in 2 CCCs or 10 MLCs studied The data suggest that IGF2 and/or H19 gene expression may be characteristic of some HCCs

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