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Title of Journal: Eur J Cardiothorac Surg

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Abbravation: European Journal of Cardio-Thoracic Surgery

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Narnia

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DOI

10.1007/bf00053846

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1010-7940

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A comparison of the performance of pig hearts perf

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Publish Date: 1994/04/01
Volume: 8, Issue: 4, Pages: 204-206
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Abstract

A comparison of the performance of pig hearts perfused with pig orhuman blood using an exvivo working heart model European Journal of CardioThoracic Surgery Volume 8 Issue 4 April 1994 Pages 204–206 https//doiorg/101016/1010794094901163The pathophysiology of xenograft hyperacute rejection is still poorlyunderstood although it is believed to involve complement fixation tovascular endothelium probably as a result of the presence of naturallyoccurring antispecies antibodies Hyperacute rejection of pig hearts byhuman blood was studied in an exvivo working heart model Cardiacperformance and immunological reactions occurring in the perfusing bloodwere studied Stroke work performed by pig hearts perfused with human bloodand their survival median 47 min n = 10 was significantly reducedcompared to survival median 158 min n = 10 and stroke work performed bypig hearts perfused with pig blood Decomplementation of human bloodresulted in improved performance and duration of the action mediansurvival 240 min n = 10 of hearts Quantitative differences wereseen in complement fixation between the groups Our data demonstrate thecentral role of complement in the destruction of pigtoman xenografts

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  1. The relevance of the microbiological flora of the upper alimentary tract to postoperative infection in major oesophageal surgery
  2. Dynamic cardiomyoplasty for long-term cardiac assist
  3. Is cerebral blood flow/metabolic mismatch during rewarming a risk factor after profound hypothermic procedures in small children?
  4. Improved spontaneous endothelialization by postfixation treatment of bovine pericardium
  5. Structural changes in implanted cardiac valvular bioprostheses constructed of glycerol-treated human dura mater
  6. Video-assisted repair of a ruptured right hemidiaphragm
  7. Recovery of end-organ failure during mechanical circulatory support
  8. Improved mitral valve replacement
  9. Pulmonary complications following myocardial revascularization with the internal mammary artery graft
  10. Video-assisted thoracoscopic treatment of pleural empyema. A newtherapeutic approach
  11. Up to 9 years of follow-up after anatomic correction of simple transposition of the great arteries
  12. Does the technique of cardiopulmonary bypass affect lung water content?
  13. Successful surgical management for multiple cerebral mycotic aneurysmsinvolving both carotid and vertebrobasilar systems in active infectiveendocarditis
  14. Warm body, cold heart surgery. Clinical experience in 2817 patients
  15. Tumor-related obstruction of the inferior vena cava extending into the right heart--a plea for surgery in deep hypothermic circulatory arrest
  16. Surgery for critical congenital aortic stenosis during the first three months of life
  17. Spontaneous rupture of the ascending aorta
  18. A concealed impalement injury of the chest--an unusual intrathoracic foreign body
  19. Coronary artery bypass surgery in patients with angina pectoris and hypothyroidism
  20. Surgical treatment of airway obstruction associated with congenital heart disease in infants and small children
  21. Sandwich repair with two sheets of equine pericardial patch for acuteposterior post-infarction ventricular septal defect
  22. Eleven years' experience with Carpentier-Edwards biological valves in relation to survival and complications
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