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Title of Journal: Pediatr Radiol

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Abbravation: Pediatric Radiology

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Springer-Verlag

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DOI

10.1016/0002-9343(83)90792-1

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1432-1998

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In vivo MRI measurement of blood oxygen saturation

Authors: Lynne E Nield XiuLing L Qi Emanuela R Valsangiacomo Christopher K Macgowan Graham A Wright Lisa K Hornberger ShiJoon Yoo
Publish Date: 2004/10/14
Volume: 35, Issue: 2, Pages: 179-185
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Abstract

Objective The purpose of this prospective study was to measure in vivo blood oxygen saturation O2 by MRI in children with congenital heart disease CHD using populationbased values for T2O T2 signal decay of fully oxygenated blood and K a parameter representing the deoxyhemoglobin effect and compare the O2 with direct cardiac catheterization measurements Background MRI can determine O2 using in vivo measurement of signal decay T2 and an in vitro calibration curve relating T2 and O2 based on the equation 1/T2=1/T2O+K1−O2/1002 Recent studies have correlated the T2/O2 in children with CHD with the adult calibration statistics Methods A total of ten children five male five female with single ventricle CHD median age 48 months range 2 months to 44 years undergoing cardiac catheterization were included in the study The blood T2 measurements for each patient were performed in a 15 T GE CV scanner The O2 was then calculated based on the equation using values of T2O determined from individual hematocrits and a population average value of K derived for children The O2 values were compared with direct O2 measurements from cardiac catheterization Results The O2 values by MRI were strongly correlated with direct cardiac catheterization measurements R=0825 P0001 Conclusion The study indicates that the noninvasive measurement of O2 by MRI can accurately measure oxygen saturation in children with complex CHD

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