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Title of Journal: Eur J Appl Physiol

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Abbravation: European Journal of Applied Physiology

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Springer-Verlag

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DOI

10.1007/s10620-011-1615-0

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1439-6327

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Targeted brain hypothermia induced by an interstit

Authors: Yunjian Wang Liang Zhu
Publish Date: 2007/04/12
Volume: 101, Issue: 1, Pages: 31-40
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Abstract

In this study the feasibility of a newly developed interstitial cooling device inserted into the neck muscle and placed on the surface of the common carotid artery is evaluated A combination of vascular model and continuum model is developed to simulate the temperature fields in both the neck and brain regions Parametric studies are conducted to test the sensitivity of various factors on the temperature distribution It has been shown that the length of the device temperature of the device and the tissue gap between the device and the blood vessel are the dominant factors that determine the effectiveness of this cooling approach Under the current design parameters the device is capable of inducing a temperature drop of 28°C along the common carotid artery and it results in a total of 90 W of heat carried away from the arterial blood Although the degree of the cooling in the arterial blood is inversely proportional to the blood flow rate of the arteries the total heat loss from the arterial blood does not vary significantly if the blood flow rate changes during the cooling After the cold arterial blood is supplied to the brain hemisphere temperature reduction in the brain tissue is almost uniform and up to 31°C temperature drop is achieved within 1 hour In addition to the possible benefits of brain hypothermia for stroke or head injury patients the device has the potential to control fever as well as to improve patients’ outcome during open neck and head surgeryThe authors would like to thank Drs Axel J Rosengart and Huan Wang for their insightful comments Financial assistance by an NSFsupported UMBC ADVANCE program is gratefully acknowledged The research was performed in partial fulfillment of the requirements for the PhD degree from the University of Maryland Baltimore County by Yunjian Wang

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