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Title of Journal: Eur J Appl Physiol

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Abbravation: European Journal of Applied Physiology

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Springer-Verlag

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DOI

10.1007/bf01619822

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1439-6327

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Exhaustive exercise reduces TNFα and IFNα produc

Authors: Hiromi Yano Masataka Uchida Ryosuke Nakai Kenji Ishida Yasuko Kato Noriaki Kawanishi Daisuke Shiva
Publish Date: 2010/07/03
Volume: 110, Issue: 4, Pages: 797-803
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Abstract

Stressful exercise results in temporary immune depression However the impact of exercise on the immune responses via tolllike receptor TLR 7 which recognizes the common viral genomic feature singlestranded RNA remains unclear To clarify the effect of stressful exercise on immune function in response to viral infection we measured the changes in the plasma concentration of tumor necrosis factor TNFα and interferon IFNα which are induced downstream from the TLR–ligand interaction in exhaustiveexercised mice immediately after treatment with the imidazoquinoline R848 which can bind to and activate TLR7 Both exhaustiveexercised EX and nonexercised NEX male C3H/HeN mice were injected with R848 5 mg kg−1 and blood samples were collected In addition RAW264 cells which are mouse macrophage cells were cultured 30 min after epinephrine 10 μM or norepinephrine 10 μM treatments and were then stimulated with R848 10 μg ml−1 In addition the effect of propranolol 10 mg kg−1 as blockade of βadrenergic receptors on R848induced TNFα and IFNα production in the exercised mice was examined Both the TNFα and IFNα concentrations in the plasma of EX were significantly lower than those in the plasma of NEX after R848 injection P  005 and P  001 respectively although the R848 treatment increased the plasma TNFα and IFNα concentrations in both groups P  001 respectively The R848induced TNFα production in RAW264 cells was significantly inhibited by epinephrine and norepinephrine pretreatment although IFNα was not detected The propranolol treatment completely inhibited exerciseinduced TNFα and IFNα suppression in response to R848 in the mice These data suggest that EX induces a reduction in TNFα and IFNα production in response to R848 and that these phenomena might be regulated by an exerciseinduced elevation of the systemic catecholamines

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