Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Eur J Appl Physiol

Search In Journal Title:

Abbravation: European Journal of Applied Physiology

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

ISSN

1439-6327

Search In ISSN:
Search In Title Of Papers:

Kidneysynthesized erythropoietin is the main sour

Authors: AnneKristine Meinild Lundby Stefanie Keiser Christoph Siebenmann Leonhard Schäffer Carsten Lundby
Publish Date: 2014/02/15
Volume: 114, Issue: 6, Pages: 1107-1111
PDF Link

Abstract

Erythropoietin EPO is mainly synthesized within renal peritubular fibroblasts and also other tissues such as the liver possess the ability However to what extent nonkidney produced EPO contributes to the hypoxiainduced increase in circulating EPO in adult humans remains unclearWe aimed to quantify this by assessing the distribution of EPO glycoforms which are characterized by posttranslational glycosylation patterns specific to the synthesizing cell The analysis was performed on samples obtained in seven healthy volunteers before during and after 1 month of sojourn at 3454 m altitudeUmbilical cord UC plasma served as control As expected a peak p  005 in urine 23 ± 05fold and plasma 33 ± 05fold EPO was observed on day 1 of highaltitude exposure and thereafter the concentration decreased for the urine sample obtained after 26 days at altitude but remained elevated p  005 by 15 ± 02fold above the initial sea level value for the plasma sample The EPO glycoform heterogeneity in the urine samples collected at altitude did not differ from values at sea level but were markedly lower p  005 than the mean percent migrated isoform PMI for the umbilical cord samplesOur studies demonstrate 1 UC samples express a different glycoform distribution as compared to adult humans and hence illustrates the ability to synthesis EPO in nonkidney cells during fetal development 2 as expected hypoxia augments circulating EPO in adults and the predominant source here for remains being kidney derived

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. A comparison of dual energy X-ray absorptiometry and bioelectrical impedance analysis to measure total and segmental body composition in healthy young adults
  2. Influence of exercise on the circulating levels and macrophage production of IL-1β and IFNγ affected by metabolic syndrome: an obese Zucker rat experimental animal model
  3. The Wingate anaerobic test’s past and future and the compatibility of mechanically versus electro-magnetically braked cycle-ergometers
  4. Strain and elongation of the vastus lateralis aponeurosis and tendon in vivo during maximal isometric contraction
  5. Influence of exercise intensity and joint angle on endurance time prediction of sustained submaximal isometric knee extensions
  6. Ventilatory responses to hypercapnia in divers and non-divers: effects of posture and immersion
  7. Erratum to: Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration
  8. The influence of aspirin on exercise-induced changes in adrenocorticotrophic hormone (ACTH), cortisol and aldosterone (ALD) concentrations
  9. Does central fatigue exist under low-frequency stimulation of a low fatigue-resistant muscle?
  10. Comparison in eccentric exercise-induced muscle damage among four limb muscles
  11. No changes in lung function after a saturation dive to 2.5 MPa with intermittent reduction in $$ P_{{{{\rm O}}_{{{\rm 2}}} }} $$ during decompression
  12. Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice
  13. Changes in body composition in triathletes during an Ironman race
  14. Endurance rather than sprint running training increases left ventricular wall thickness in female athletes
  15. Age-related fascicle–tendon interaction in repetitive hopping
  16. Basic reporting and interpretation of surface EMG amplitude and mean power frequency: a reply to Vitgotsky, Ogborn, and Phillips
  17. Non-thermal modification of heat-loss responses during exercise in humans
  18. Changes in cerebral oxygenation during parabolic flight
  19. Targeted brain hypothermia induced by an interstitial cooling device in human neck: theoretical analyses
  20. Characterizing cerebral and locomotor muscle oxygenation to incremental ramp exercise in healthy children: relationship with pulmonary gas exchange
  21. Effects of resistance training on neuromuscular characteristics and pacing during 10-km running time trial
  22. Lowering of resting core temperature during acclimation is influenced by exercise stimulus
  23. A physiological counterpoint to mechanistic estimates of “internal power” during cycling at different pedal rates
  24. Strenuous exercise increases late outgrowth endothelial cells in healthy subjects
  25. Plasma glucose, insulin and catecholamine responses to a Wingate test in physically active women and men
  26. Activation amplitude patterns do not change for back muscles but are altered for abdominal muscles between dominant and non-dominant hands during one-handed lifts
  27. Energetics of paraplegic cycling: a new theoretical framework and efficiency characterisation for untrained subjects
  28. Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome
  29. Peak lifting velocities of men and women for the reduced inertia squat exercise using force control
  30. A comparison of respiratory compensation thresholds of anaerobic competitors, aerobic competitors and untrained subjects
  31. Ergonomic comparison of a chem/bio prototype firefighter ensemble and a standard ensemble
  32. Heart rate recovery and parasympathetic modulation in boys and girls following maximal and submaximal exercise
  33. Maximal voluntary contraction force, SR function and glycogen resynthesis during the first 72 h after a high-level competitive soccer game
  34. K + potentiates hyperosmolarity-induced vasorelaxations in rat skeletal muscle arterioles
  35. Circadian variation in the circulatory responses to exercise: relevance to the morning peaks in strokes and cardiac events
  36. Characteristics of sweating responses and peripheral sweat gland function during passive heating in sprinters
  37. Estimation of hand and wrist muscle capacities in rock climbers
  38. Body regional influences of l -menthol application on the alleviation of heat strain while wearing firefighter’s protective clothing
  39. Seasonal changes in leg strength and vertical jump ability in internationally competing ski jumpers
  40. Respiratory muscle training reduces the work of breathing at depth
  41. Studies on inspiratory and expiratory glossopharyngeal breathing in breath-hold divers employing magnetic resonance imaging and spirometry
  42. Effects of combined resistance and cardiovascular training on strength, power, muscle cross-sectional area, and endurance markers in middle-aged men
  43. The surface mechanomyogram as a tool to describe the influence of fatigue on biceps brachii motor unit activation strategy. Historical basis and novel evidence
  44. Effect of lecturing to 200 students on heart rate variability and alpha-amylase activity
  45. Influence of crank length and crank width on maximal hand cycling power and cadence
  46. Effects of altitude exposure on brain natriuretic peptide in humans
  47. Do greater rates of body heat storage precede the accelerated reduction of self-paced exercise intensity in the heat?
  48. Perceived exertion and maximal quadriceps femoris muscle strength during dynamic knee extension exercise in young adult males and females
  49. The effect of an active warm-up on surface EMG and muscle performance in healthy humans
  50. Comparison of two waist-mounted and two ankle-mounted electronic pedometers
  51. Mechanical and physiological effects of varying pole weights during Nordic walking compared to walking
  52. Physiological and psychological reactions to work in men and women with identical job tasks
  53. Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method
  54. Seventy-year-old habitual volleyball players have larger tibial cross-sectional area and may be differentiated from their age-matched peers by the osteogenic index in dynamic performance
  55. Physiological costs and temporo-spatial parameters of walking on a treadmill vary with body weight unloading and speed in both healthy young and older women
  56. Hot water immersion induces an acute cytokine response in cervical spinal cord injury
  57. Diurnal physiological and immunological responses to a 10-km run in highly trained athletes in an environmentally controlled condition of 6 °C
  58. Diurnal physiological and immunological responses to a 10-km run in highly trained athletes in an environmentally controlled condition of 6 °C
  59. Effects of low ambient temperature on heart rate variability during sleep in humans
  60. Inhomogeneous architectural changes of the quadriceps femoris induced by resistance training
  61. Effects of short-term corticoid ingestion on food intake and adipokines in healthy recreationally trained men
  62. Effect of exercise on the diurnal variation in energy substrate use during a high-fat diet
  63. Pathophysiological adaptations to walking and cycling in primary pulmonary hypertension
  64. Intracortical inhibition in the soleus muscle is reduced during the control of upright standing in both young and old adults
  65. Inflammatory, lipid, and body composition responses to interval training or moderate aerobic training
  66. Selection of military survival gears using thermal manikin and computer survival model data
  67. RhEPO improves time to exhaustion by non-hematopoietic factors in humans
  68. Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins
  69. Mechanomyographic assessment of contractile properties within seven segments of the human deltoid muscle
  70. Differences in conductive foot cooling: a comparison between males and females
  71. Increased endothelial microparticles and oxidative stress at extreme altitude
  72. Attentional, emotional and hormonal data in subjects of different ages
  73. Leptin signaling in skeletal muscle after bed rest in healthy humans
  74. Attentional, emotional and hormonal data in subjects of different ages
  75. Attentional, emotional and hormonal data in subjects of different ages
Search Result: