Authors: Hatsuo Yamamura Kousuke Satake Rieko Hirasawa Shinichi Yamada Masao Kawai
Publish Date: 2007/01/19
Volume: 57, Issue: 1-4, Pages: 261-264
Abstract
A novel cyclodextrin CD dimer linked with a bispicolinylcystine Cys moiety was prepared by the coupling of Bocprotected Cys with aminomodified CDs followed by deprotection of the Boc groups and bispicolinylation The dimer showed less affinity to an organic guest molecule compared to that of a native CD monomer It was attributed to an intramolecular inclusion of the pyridine moiety into CD cavity The dimer caused significant increase of its organic guest affinity by an addition of a copper ion The included pyridine group may come out of a CD cavity to bind the copper ion and the two CDs included cooperatively and intermolecularly a guest molecule with high affinity
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