Journal Title
Title of Journal: J Incl Phenom Macrocycl Chem
|
Abbravation: Journal of Inclusion Phenomena and Macrocyclic Chemistry
|
Publisher
Springer Netherlands
|
|
|
|
|
|
Authors: Zlata Tofzikovskaya Alan Casey Orla Howe Christine O’Connor Mary McNamara
Publish Date: 2014/07/16
Volume: 81, Issue: 1-2, Pages: 85-94
Abstract
Many chemotherapeutic drugs are therapeutically nonselective and do not distinguish between healthy cells and tumour cells which can result in severe side effects and toxicity Drug delivery systems can be used to target specific cells and therefore may eliminate many of the side effects increasing drug efficiency and efficacy and controlling drug release One possible strategy for targeted drug delivery is to use unique molecular markers such as folate receptors in cancer cells In this work the cytotoxicity of a novel cyclodextrinfolate conjugate 6deoxy612aminoethylaminofolateβcyclodextrin CDEnFA was studied using the MTT assay and the MCF7 Breast HeLa Cervical A549 Lung cancer and BEAS2B normal Lung cell lines The MTT assay showed that the drug delivery vehicle CDEnFA is not cytotoxic towards the cell lines studied even towards the normal BEAS2B cell line and therefore it is expected that it is safe for medical use The inclusion complex CDEnFAMTX has superior cytotoxic activity towards all of the cancer cell lines studied compared to the drug MTX alone and CDEnFAMTX is four times less cytotoxic than the drug towards the normal cell line The observed toxicity is attributed solely to MTX since CDEnFA did not exhibit significant cytotoxicity These results also suggest that the drug remains bioactive even after inclusion in the CD cavity The cytotoxicity trend observed for CDEnFAMTX in this study is MCF7 Breast A549 Lung HeLa Cervical BEAS2B normal Lung
Keywords:
.
|
Other Papers In This Journal:
- Cytosine: para -sulphonato-calix[4]arene assemblies: in solution, in the solid-state and on the surface of hybrid silver nanoparticles
- Thermodynamic stability of C 3 H 8 hydrate of cubic structure IV using lattice dynamics
- β-Cyclodextrin/protein conjugates as a innovative drug systems: synthesis and MS investigation
- Pre-formulation of an oral cyclosporine free of surfactant
- Vibrational dynamics and hydrogen bond properties of β-CD nanosponges: an FTIR-ATR, Raman and solid-state NMR spectroscopic study
- Improved aqueous Cannizzaro reaction in presence of cyclodextrin
- The solid-state structures of the ethanol solvated complexes of para -sulphonato-calix[4]arene with magnesium and calcium ions
- Design and evaluation of folate-appended methyl-β-cyclodextrin as a new antitumor agent
- 8-Hydroxyquinoline Based Multipodal Systems: Effect of Spatial Placement of 8-Hydroxyquinoline on Metal Ion Recognition
- Thiacalixarenes: emergent supramolecules in crystal engineering and molecular recognition
- Synthesis and characterization of new organocobaloxime derivatives with asymmetric dioxime ligands
- Encapsulation and Release Characteristics of Carbon Dioxide in α-Cyclodextrin
- Molecular dynamics simulation and quantum chemical studies on the investigation of aluminum nitride nanotube as phosgene gas sensor
- Synthesis, structure and property of three divalent metal complexes of the piperidinoacetyl-containing calix[4]arene
- Sorption onto insoluble β-cyclodextrin polymer for 2,4-dinitrophenol
- Glycation of human serum albumin affects its binding affinity towards (−)-epigallocatechin gallate
- Organotellurium-bridged cyclodextrin dimers as artificial glutathione peroxidase models
- Interactions of cyclodextrins with aromatic amino acids: a basis for protein interactions
- Naphthyridine amide–urea conjugate: a case toward selective fluorometric sensing of N -acetyl proline carboxylate
- A novel switch-on fluorescent receptor for bromide based on an amide group
- Thermodynamics of ZrO 2+ cation complexation with dibenzo-18-crown-6 in mixed non-aqueous solvents
- A computational study of hydrogen cyanide interaction with the pristine and B, Ga, BGa-doped of (8, 0) zigzag AlPNTs
- Selective Pseudo-Rotaxane Type Complex Formation of Zinc(II) ( t -butylatedtetraphenyl) porphyrin-Viologen Linked Compounds with tri- O -methyl-β-Cyclodextrin
- Controlled release of antifungal volatiles of thyme essential oil from β-cyclodextrin capsules
- Synthesis, crystal structure and spectroscopic studies of copper(II) complex of C -meso-1,5,8,12-tetramethyl-1,4,8,11-tetraazacyclotetradecane
- Sorption of azo dyes from aqueous solutions by tetradodecyloxybenzylcalix[4]resorcinarene derivatives
- Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery
- Thermodynamics of cesium complexes formation with 18-crown-6 in ionic liquids
- Determination of the ionization constants of natural cyclodextrins by high-resolution 1 H-NMR and photon correlation spectroscopy
- Monosodium salt of p-tert -butylcalix[4]arene in the reactions with electrophilic reagents. Synthesis and structure of monofunctionalized calix[4]arenes
- Paramagnetic properties and molecular structure of coordination saturated inclusive lanthanide complexes with 18-crown-6 using NMR
- Inclusion complex formation of α- and β-cyclodextrins with aminobenzoic acids in aqueous solution studied by 1 H NMR
- Preparation of a cyclodextrin dimer linked with a bis(picolinyl)cystine moiety and its intra- and intermolecular inclusion behavior
- Machines in art and chemistry
|