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Title of Journal: J Incl Phenom Macrocycl Chem

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Abbravation: Journal of Inclusion Phenomena and Macrocyclic Chemistry

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Springer Netherlands

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DOI

10.1016/0734-9750(93)90439-T

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ISSN

1573-1111

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Design and evaluation of folateappended methylβ

Authors: Risako Onodera Keiichi Motoyama Hidetoshi Arima
Publish Date: 2010/08/21
Volume: 70, Issue: 3-4, Pages: 321-326
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Abstract

Methylβcyclodextrin MβCyD is widely used as a raft disrupting agent through extraction of cholesterol from lipid rafts which are highly expressed in cell membranes of tumor cells but it does not have tumor cellselective action Meanwhile the widespread use of folic acid FA as a tumortargeting ligand has been known because folate receptor FR overexpresses in various kinds of epithelial tumor cells In the present study in order to obtain more tumor cellselectivity and antitumor activity of MβCyD we designed folateappended MβCyD FAMβCyD and evaluated its physicochemical properties and antitumor activity The 1HNMR study demonstrated that FAMβCyD having average degree of substitution of FA DSF of 10 was prepared In addition FAMβCyD DSF 10 was found to be amorphous in a solid state and surfaceactive Importantly FAMβCyD DSF 10 had potent cytotoxicity compared to MβCyD in KB cells but not in A549 cells These results suggest that FAMβCyD DSF 10 has the potential as a novel antitumor agent

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  7. The solid-state structures of the ethanol solvated complexes of para -sulphonato-calix[4]arene with magnesium and calcium ions
  8. 8-Hydroxyquinoline Based Multipodal Systems: Effect of Spatial Placement of 8-Hydroxyquinoline on Metal Ion Recognition
  9. Thiacalixarenes: emergent supramolecules in crystal engineering and molecular recognition
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  11. Encapsulation and Release Characteristics of Carbon Dioxide in α-Cyclodextrin
  12. Molecular dynamics simulation and quantum chemical studies on the investigation of aluminum nitride nanotube as phosgene gas sensor
  13. Synthesis, structure and property of three divalent metal complexes of the piperidinoacetyl-containing calix[4]arene
  14. In vitro evaluation of the cytotoxicity of a folate-modified β-cyclodextrin as a new anti-cancer drug delivery system
  15. Sorption onto insoluble β-cyclodextrin polymer for 2,4-dinitrophenol
  16. Glycation of human serum albumin affects its binding affinity towards (−)-epigallocatechin gallate
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